Báo cáo khoa học: Scaffolds are ‘active’ regulators of signaling modules doc

... MINIREVIEW Scaffolds are ‘active’ regulators of signaling modules Anita Alexa, Ja ´ nos Varga and Attila Reme ´ nyi Department of Biochemistry, Eo ¨ tvo ¨ s Lora ´ nd ... Interest- ingly, release of 14-3-3 dimer opens the scaffold’s FXFP docking site for activated ERK [39], so all the active components of the RAF–MEK–ERK signaling module are colocalized at the site...

Ngày tải lên: 06/03/2014, 23:20

... visual similarity of characters by 2×(the area of overlap between character A and B)/ (area of character A+area of character B) follow- 375 Not Repeated / Repeated Deletion Ratio of Freq. 0.0 0.4 ... transposition of adjacent char- acters and 2 a transposition skipping a character, the instances in en keystroke are mostly of distance of 1, while in ja keystroke, the distance...

Ngày tải lên: 19/02/2014, 19:20

... 17-fold enhancement of GL binding to the wild-type upon the addition of the same concentration of phosphate. pH profiles The pH dependences of logarithmic rates of the H334G mutant and wild-type are compared ... elevation of pK a of PLP phosphate in unliganded CcStP and the apparent lack of perturbation of pK a in the CcStP complex with arsenate. The pH dependence of the...

Ngày tải lên: 23/03/2014, 07:20

... aggregation in the presence of a mixture of annexins of different subtypes. The profile of liposome aggregation was simply the sum of the results obtained with a single subtype of annexin, sug- gesting ... biology of conditional association Naofumi Miwa 1 , Tatsuya Uebi 2, * and Satoru Kawamura 2,3 1 Department of Physiology, School of Medicine, Toho University, Tokyo, Japan...

Ngày tải lên: 18/02/2014, 14:20

... of parent node in dependency tree. c-word: word of child node. p-pos: POS of parent node. c-pos: POS of child node. p-pos+1: POS to the right of parent in sentence. p-pos-1: POS to the left of ... of features, which can be seen in Table 1c. Features of the first type look at words that occur between a child and its parent. These features take the form of a POS trigram: the PO...

Ngày tải lên: 20/02/2014, 15:20

... consists of 250 documents: the 100 MUC-6 training docu- ments and 150 WSJ documents which we retrieved using a set of keywords and categorized manually. The curves labeled Mono, Counter and Baseline are as ... differences are: a. the data-points in (Yan- garber et al., 2002) are instances of names in text (which are to be labeled with their semantic cate- gories), whereas here th...

Ngày tải lên: 20/02/2014, 16:20

... cut-off point for the WSJ. This becomes apparent when one takes a look at where the 59 ambiguous variation nuclei arise: 32 of them are variation nuclei of 6-grams, 10 are part of 7-grams, 4 are ... element of the variation n-gram. The two exceptions are "and use some of the pro- ceeds to" and "buy and sell big blocks of& quot;, where the variation nuclei...

Ngày tải lên: 22/02/2014, 02:20

... maximized when we rely on syntactic rules defined in terms of part -of- speech at the cost of a high degree of ambiguity. Thus, the goal of maximizing the parsing coverage while minimizing the ... results of the technique on the basis of two sets of unseen test data. In section 5 we discuss system engineering issues to accommodate the proposed technique, i.e., integration...

Ngày tải lên: 22/02/2014, 03:20

... meaning. 6.3 Size of the Reference Corpus Another area of investigation is the repercus- sions of the choice of the corpus for the reference (adult) model. The size (and content) of the corpus ... approx. 300 dimensions are retained 2 UΣ is used to project word vectors into V-space SVD x x Document,VectorsWord,Vec tors Original,Matrix word, 1 word, 2 word, n doc, 1 doc, 2...

Ngày tải lên: 07/03/2014, 22:20

... be the early recognition of ‘off target’ and side effects of drug candidates [7], as well as the identifica- tion of putative biomarkers. The phosphorylation status of signaling pathway components ... protein micro- array [8–10]. Signaling pathways in health and disease Fundamental cellular processes are under tight control of signaling pathways, many of which are highly...

Ngày tải lên: 16/03/2014, 00:20