Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf
Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf
... 2010 FEBS Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages The´re`se He`rve´e Mayi1,2,3,4, Christian Duhem1,2,3,4, Corinne Copin1,2,3,4, ... alsoincreased (Fig. 1G,H). Taken together, these dataAcLDL12 Visfatin/ cyclophilin mRNAVisfatin/cyclophilin mRNA Visfatin/ cyclophilin mRNACD36/cyclophilin mRNAFABP4/cyclophilin mRNA Visfatin/ cyclophilin ... gene in human macrophages. Interestingly,PPARc activation enhanced visfatin gene expression in both M1 and M2 human macrophages, but not in murine macrophages or in human adipocytes. Finally,we...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... reversed by oral and intravenous administration ofL-arginine. ThustheL-arginine transport through the membrane exerts aregulatory role in the pathwayL-arginine/NO. In most mammalian cells arginine ... membrane.Moreover system y+L is inhibited by L-leucine in thepresence, but not in the absence of Na+.The small inhibition ofL-arginine in ux by L-leucine in the absence of Na+could ... buffer containing 2 mMCaCl2,werepre-warmed at 37 °Cfor10minwithN-ethylmaleimide andincubated withL-arginine andL-leucine when required.Incubation was stopped by sonicating samples in ice.Suitable...
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Báo cáo khoa học: PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans doc
... proteins and serum proteins[2,3]. Fitting with its role in cholesterol metabolism,PCSK9 is highly expressed in the liver and intestine,two tissues important in cholesterol homeostasis [4]. It is ... FEBSendogenous inhibitor, a catalytic domain characteristicof serine proteases and a C-terminal Cys- and His-richdomain implicated in enzyme stability and protein–protein interaction [3]. ... PAGE. Following electropho-resis, gels were dried and visualized by phosphorimagingusing a Typhoon Imager. Signals were quantified usingimagequant 5.2 software using the integer integrationmethod...
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Báo cáo khoa học: Protein oligomerization induced by oleic acid at the solid–liquid interface – equine lysozyme cytotoxic complexes potx
... during ELOA unfolding, which is adistinguishing feature of the first transition in equinelysozyme [39,46]. This indicates that the confor-mational changes in ELOA and equine lysozymealone ... Haemek, Israel). Cellswere maintained in culture media containing 10% fetalbovine serum (Biological Industries), then sedimented by centrifugation for 10 min at 400 g and resuspended in 100 ... Protein folding revisited. A poly-peptide chain at the folding–misfolding–nonfoldingcross-roads: which way to go?. Cell Mol Life Sci 60,1852–1871.2 Dobson CM (2003) Protein folding and misfolding.Nature...
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Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx
... The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumornecrosis factor-alpha and by ultraviolet B radiation.J Clin Invest 92, 462–470.22 Kristensen M, Chu CQ, Eedy ... were interested to knowwhether factors involved in maintaining epidermalhomeostasis affect DNp63a expression. We were par-ticularly interested in tumor necrosis factor-a (TNF-a),as this pleiotropic ... may be involved. This is consistent withprevious findings demonstrating a role for NF-jBinantagonizing keratinocyte proliferation and regulatingepithelial cell differentiation [24,25]. In our...
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Báo cáo khoa học: Nitric oxide-induced epidermal growth factor-dependent phosphorylations in A431 tumour cells pot
... cells by measuring the incorporation of[methyl-3H]thymidine into DNA. Figure 1 shows that theNO•donor DEA-NO strongly inhibits this process in aFig. 1. NO•inhibits DNA synthesis by a ... these kinases is the family ofp38MAPKs [19–23], which are activated by dual tyrosine/threonine kinases responsive to pro -in ammatory cytokinesand environmental stress [24]. However, there is increasingevidence ... protein that containsphosphorylated Tyr204) and to phospho-specific c-JunN-terminal kinases 1 and 2 (JNK1/2) (G-7) (developed in mouse against a conserved segment of the human proteinscontainingphosphorylated...
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Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... Jarai,Z.,Fezza,F.,Miura,G.I.,Palmiter,R.D.,Sugiura,T.&Kunos,G. (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410, 822–825.11. Harvey, J . & Ashford, M.L. (2003) Leptin in the CNS: much morethan ... (Th1) and Th2 cytokines [4], which are critical in regulating embryo implantation and materno-fetalexchanges [5,6]. Leptin signaling is mediated by the longisoform of the leptin receptor (LR) via ... Anti -human insulin-likegrowth factor I receptor (anti-IGF-IR) and human leptin receptor/ Fc chimeras (soluble LR, sLR) were purchasedfrom R & D Systems (Minneapolis, MN, USA). Accordingto...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies of hunt-ingtin, a protein possessing ... virusvectors containing an extracellular superoxide dis-mutase (SOD) are administered by intramyocardialinjection, yielding long lasting protection against isc-hemia ⁄ reperfusion injury in rats [158]. ... Synthesis ofexogenous human aA-crystallin in lens epithelial cellsof the same species counters UVB -induced apoptosis by favoring action of the AKT kinase pathway, poten-tially explaining results...
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Tài liệu Báo cáo khoa học: "Peeling Back the Layers: Detecting Event Role Fillers in Secondary Contexts" pdf
... 17th International Joint Confer-ence on Artificial Intelligence.J. Finkel, T. Grenager, and C. Manning. 2005. Incor-porating Non-local Information into Information Ex-traction Systems by Gibbs ... roles.This produced 3,092 positive training sentences. Allremaining sentences that do not contain any answerkey strings are used as negative instances. This pro-duced 19,313 negative training ... On-demand information ex-traction. In Proceedings of Joint Conference of theInternational Committee on Computational Linguis-tics and the Association for Computational Linguistics(COLING/ACL-06.Y....
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Báo cáo khoa học: Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruzi pdf
... GTP-binding protein, putative 1RNA-binding protein 5, putative 1RNA-binding protein, putative 1Serine acetyltransferase, putative 1Serine ⁄ threonine protein phosphatase, putative 1Serine ... proteins in additionto TcDHH1, including heat shock proteins, mRNA-binding proteins, initiation and elongation translationfactors, ribosomal proteins and metabolic proteins.Abundant proteins, ... fly intestine [1]. Trypanosoma cruzi exists in itsamastigote form in the cytoplasm of the mammalinfected cell, or as an epimastigote in the kissing bugintestine [2]. Protozoans of the Leishmania...
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