... isrequired for solid tumor formation and embryonic vas-cularization. EMBO J 17, 3005–3015.18 Tomita S, Ueno M, Sakamoto M, Kitahama Y,Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda Net ... 57,178–201.14 Maltepe E & Simon MC (1998) Oxygen, genes, anddevelopment: an analysis of the role of hypoxic generegulation during murine vascular development. J MolMed 76, 391–401.15 Hickey MM & ... consequent event of brain macrophages is oneof the most important defense mechanisms used by thebrain. However, this phenomenon sometimes leads toneuroinflammatory disorders, such as multiple sclerosis[83]...