... Victoria, Australia3 INSERM U428, Faculte´de Pharmacie, Universite´Paris V, Paris, France4 Departments of Pathology and Laboratory Medicine, Pharmacology, and Medicine, Carolina Cardiovascular ... FEBS(GAGs) [3]. Glycosaminoglycans such as heparin, hep-aran sulfate and dermatan sulfate have been found tosignificantly accelerate the interaction between serpinsand coagulation proteases, usually ... Calcium enhances heparin catalysisof the antithrombin-Factor Xa reaction by a templatemechanism: Evidence that calcium alleviates Gladomain antagonism of heparin binding to Factor Xa.J Biol...