Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc

... compilation ª 2010 FEBS 2583 REVIEW ARTICLE Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock -in (Hupki) mouse model Jill E. Kucab, David H. Phillips ... model for studying human TP53 mutagenesis is the partial human TP53 knock -in (Hupki) mouse containing exons 4–9 of human TP53...

Ngày tải lên: 06/03/2014, 11:20

... capturing the contextual information required for temporal linking. The remainder of this paper goes into the de- tails of our approach for temporal linking, and presents empirical evidence for the ... IC domain 2. Linking Timestamps and Relations in the IC domain 3. Linking Events to Temporal Expressions (TempEval-2, task C) The first two data sets contained annotations...

Ngày tải lên: 24/03/2014, 03:20

... acceptor. NP, MP, and HPO are all DHNA inhibitors. The binding of the inhibitors to the enzymes cause a decrease in their fluorescence intensities. The increasing fluorescence intensities in Fig. ... 5A were obtained by subtracting the control titration data in the absence of the enzymes from the titration data in the presence of the enzymes. The results of the...

Ngày tải lên: 19/02/2014, 00:20

... TiMBL-core uses only the examples found in the page for the sense being trained. • TiMBL-inlinks uses the examples found in Wikipedia pages pointing to the sense being trained. • TiMBL-all uses ... word in the Wikipedia page for the word sense; (ii) occurrences of the word in Wikipedia pages pointing to the page for the word sense; (iii) occurrences of the wo...

Ngày tải lên: 20/02/2014, 04:20

... duration of symptoms. For example, key questions about chest pain include intensity, loca- tion, duration, quality of pain, and factors that in- crease or decrease the pain. These answers to these questions ... (e.g. pointing to an area of the body). This is clearly a domain in which the constraints of the task are suf- ficient for a limited domain, one way spoken trans- lation...

Ngày tải lên: 20/02/2014, 16:20

... language learners—by displaying them in the original con- text. The following functions are provided: Filtering and sorting The results which will be displayed can be selected according to seve- 47 ... and the aligned context in the target language, English. The extractor is designed as a module which is plugged into the parser. After a sentence from the source corpus i...

Ngày tải lên: 22/02/2014, 02:20

... focusing, i.e. enabling the evaluator to choose from the encyclopedia the pieces of knowledge which are expected to be relevant to the current importance evaluation. The use of the goal in ... domain specific knowledge contained in the encyclopedia. The IF-part of the rules contains conditions that are evaluated with respect to the current HPN (initially...

Ngày tải lên: 09/03/2014, 01:20

... but instead of building into concentric layers to form the walls of the heart, the myocardial cells form into a single layer, resulting in a dilated, thin-walled heart whose structure is reminis- cent ... belong to a family of kinases that are thought to act upstream of the mitogen-activated protein kinas- es (see the accompanying minireview [11] on the bio- chemical inter...

Ngày tải lên: 15/03/2014, 10:20

... ethanolamine). The circles show the fit to the data obtained on analysis with the 1 : 1 Langmuir binding model for evaluation of the kinetic rate constants. (B) Sensorgram showing the binding of Tom70 ... Langmuir binding model showed a good fit (Fig. 6A) for the monovalent analyte (12F-11) binding to a Tom70 epitope consistent with a 1 : 1 binding interaction. There was n...

Ngày tải lên: 17/03/2014, 10:20

... neurotrophic factor for motor neurones in vitro and in vivo in the rat [11,12]. In liver recombinant HIP/PAP has been shown to promote the adhesion of rat hepatocytes and to bind elements of the extracellular ... serines 73 and 138 and threonine 153 of the HIP/PAP protein for alanines. Oligonucleotides cas- settes containing the desired mutations were inserted into pcD...

Ngày tải lên: 23/03/2014, 13:20