Báo cáo khoa học: ATP allosteric activation of atrial natriuretic factor receptor guanylate cyclase pot

... 2010) doi:10.1111/j.1742-4658.2010.07670.x Atrial natriuretic factor receptor guanylate cyclase (ANF-RGC) is the receptor and the signal transducer of two natriuretic peptide hormones: atrial natriuretic factor and brain natriuretic ... ATP regulation of ANF-RGC FEBS Journal 277 (2010) 2550–2563 ª 2010 The Authors Journal compilation ª 2010 FEBS 2563 ATP allos...

Ngày tải lên: 06/03/2014, 11:20

... (2003) Tumour necrosis factor- a-induced expression of intercellular adhesion molecule-1 on human eosinophilic leukaemia EoL-1 cells is mediated by the activation of nuclear factor- jB pathway. Clin ... focal accumulation and antigen-induced activation of T cells in inflammatory demyelinating diseases of the PNS. As mentioned above, MAPKs were implicated in the activation of...

Ngày tải lên: 18/02/2014, 18:20

... with respect to the role of HSP70 in the inhi- bition of the release of Smac and apoptosis. The role of the ATP- binding domain of HSP70 in the prevention of the release of Smac and apoptosis after ... and then binds to and activates caspase-9 in the presence of dATP ⁄ ATP [9]. This leads to proteo- lytic activation of a common set of downstream prote- ases, including...

Ngày tải lên: 16/03/2014, 01:20

... formation of aggresomes [35]. This may provide a rapid means of clearing the cells of iNOS that would be detrimental to the cell because of its prolonged production of large amounts of • NO. Our ... in the presence of EDTA. The activation of nNOS and eNOS by wild-type CaM resulted in an NADPH consumption to • NO production ratio of more than 3 instead of the theoret- ica...

Ngày tải lên: 16/03/2014, 13:20

... ubiquitination of K31, together with analy- sis of PKCe knockout MEFs with knockdown of PKCd, revealed further evidence of a crucial role of K63-ubiquitination of the RING domain of TRAF2 for recruitment of ... experi- ments of TRAF2 or cIAP knockout cells with the Table 4. Effects of knockout ⁄ knockdown of components of the TNF receptor- associated factor 1 (TNFR1...

Ngày tải lên: 28/03/2014, 23:20

... MgCl 2, 100 lm ATP containing 10 lCi [ 32 P ]ATP [cP] 3000 CiÆmmol )1 (Amersham Pharmacia Biotech), 200 ng Aurora A or 50 ng JNK3 ⁄ SPAK1b or 10 ng PKA and 10–15 lL of a 50% slurry of GST fusion ... Tillit J, Kress M & Ernoult- Lange M (2008) Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A ⁄ C. Biol Cell 100, 51–61. 8 Dh...

Ngày tải lên: 07/03/2014, 01:20

... (partially) shared by some of the other seven re- searchers. Comparison with Other Hypotheses Another way of evaluating the output of B and J is to compare them with the hypotheses of other researchers. ... Mark; they then produce two hypotheses on the test text ( ˆ L test.B and ˆ L test.J ). Evaluations of these hypotheses follow. In §5.3, we compare them with the hypotheses of t...

Ngày tải lên: 08/03/2014, 02:21

... leftmost dependent of and its POS; the head of ( ), its POS and the label of the dependency ; the closest left and right siblings of (depen- dents of ) and their POS tags; the label of the dependency ... this VP|TO S|NP NP|DT Figure 1: Example of (a) the Penn Treebank WSJ annotation, (b) the output of Charniak’s parser, and the results of the conversion to dependency structu...

Ngày tải lên: 08/03/2014, 04:22

... complete loss of signal after 120 min of incubation. The strong loss of func- tion and loss of integrity observed after 60 min of incubation agree with the almost complete inhibition of mitogenic ... 3281 function of time of exposure to thrombin. Figure 8B shows that increasing times of FGF-2 ⁄ thrombin incu- bation strongly reduced both the integrity of FGF-2 (expressed a...

Ngày tải lên: 16/03/2014, 01:20

... expres- sion of the hupTUV genes from a broad host range vector could partially restore the signal transduction cascade, although irrespective of the presence of hydrogen. Each of the elements of the ... expression The HupSL enzyme of T. roseopersicina is a member of the Group 1 uptake [NiFe]-H 2 ases [16]. Many members of this group are expressed only in the pres- ence of h...

Ngày tải lên: 16/03/2014, 23:20