Báo cáo khoa học: Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain ppt

... (h) A 600 0 2 4 6 8 10 12 14 024487296 Wild-type Dcoq2 + 50 µ M CoQ 2 Dcoq2 + 50 µM decylQ Dcoq2 0 2 4 6 8 10 A 600 DCoQ CoQ 2 DecylQ A1 -Q 2 A4 -Q 2 A5 -Q 2 A6 -Q 2 A3 -Q 2 A2 -Q 2 AB O O MeO MeO A1 -Q 2 O O MeO MeO A6 -Q 2 O O MeO MeO A5 -Q 2 O O MeO MeO A4 -Q 2 O O MeO MeO A3 -Q 2 O O MeO MeO A2 -Q 2 O O MeO MeO DecylQ O O MeO MeO CoQ 2 O O MeO MeO CoQ 6 C Fig. ... ubiquinones....

Ngày tải lên: 06/03/2014, 11:20

... supershift group by KLF4 antibody. (B) Recruitment of KLF4 to the binding element of the SR-BI promoter region. The ChIP assay was used to detect the binding of KLF4 to the SR-BI promoter. The cross-linked ... THP-1 macrophages, the increment level induced by HDL 3 was much higher than that by HDL 2 . Therefore, HDL 3 was chosen as the stimulus in the subsequent...

Ngày tải lên: 18/02/2014, 04:20

... zeros, but most of them were double pre- scriptions, which were identified by the nurse or the physician. These types of errors did not occur in the PB-U, meaning they were caused by the CPOE system ... immediately visible by adding a black sign. Another problem was the request of drug plasma concentration levels. They were often being forgotten or, on the other hand,...

Ngày tải lên: 25/10/2012, 10:39

... setting, the ability of the F 0 F 1 -ATP synthase to pump protons out of the matrix represents the only component opposing the action of an uncoupler. On the basis of a recent study by Giorgio ... changes, as the percentage change in the steady-state rate of the pathway divided by the percentage change in the enzyme activity caus- ing the flux change. The...

Ngày tải lên: 14/02/2014, 19:20

... displace the dimethylbenzimidaz- ole side chain of the cobalamin-cofactor or that it may act on the binding site of the MetS allosteric cofactor, S-AdoMet, both effects which could explain the observed ... optimization of inhibitors, a molecular model of the methyltetra- hydrofolate-binding domain of the rat liver MetS was constructed. In the absence of a high-...

Ngày tải lên: 19/02/2014, 05:20

... cuvette closed by a Teflon stopper. The oxygen was consumed by most substrates within the mixing time as revealed by the immediate bleaching of the TPQ 500 nm band and by the appearance of absorption ... reaction, because of the broad band (shoulder) formed in the 350 nm region. By subtracting the spectrum of native LCAO from the spectrum of the radical,...

Ngày tải lên: 19/02/2014, 12:20

... absence of Adh4 mRNA in the stomach epithelia – the tissue with the best characterized Adh4 expression. Taken together, our results demonstrate expression of ADH3 in most of the analyzed areas in the ... particularly the striatum, can oxidize retinol to retinal, providing the first step on the way to retinoic acid [31]. The brain must thus rely on the activity of ot...

Ngày tải lên: 21/02/2014, 00:20

... inhibited by these peroxides in the absence of added Fe 2+ –EDTA. The presence of this metal-ion complex enhanced the inhibition observed with these enzymes consistent with the o ccurrence of radical- mediated ... Furthermore removal of the peroxide groups by reduction p revents enzyme inhibitio n. Such a mechanism is also supported by the inefficient inhibition of...

Ngày tải lên: 21/02/2014, 03:20

... differentiation of F9 cells were not affected by the over-expression of Hsp105a, the sensitivity of cells to oxidative stress was enhanced by the over-expression of Hsp105a,andthese findings were ... Ig.C,cytosolicfraction;M,mitochondrial fraction. (B) The densities the cytochrome c bands were quantified by densitometry, and the rates release into the cytosol are sho...

Ngày tải lên: 21/02/2014, 03:20

... inhibitor I, by about 70%; and the combination of SB203580, the JNK inhibitor I and a caspase-8 inhibitor, by 100%. These findings demonstrate the requirement for concurrent activation of the p38 kinase, ... molecular cloning techniques [48]. The cloned c-jun promoter sequences were verified by DNA sequencing (DNA sequencing service, Centre for Genomics and Proteo- mics, th...

Ngày tải lên: 07/03/2014, 12:20