Báo cáo khoa học: Human lactoferrin activates NF-jB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling potx

... 2010 The Authors Journal compilation ª 2010 FEBS Human lactoferrin activates NF-jB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling Ken ... instead of the CD 14 LPS complex, may be presented to TLR4, thereby triggering TLR4 activation through the carbo- hydrate chains of hLF. Howe...

Ngày tải lên: 06/03/2014, 11:20

... )980 .44 )1020.5 Distance to the catalytic triad (A ˚ ) Ser2308 4. 93 2 .40 4. 00 3. 14 Asp2338 2.98 3.98 4. 14 4.81 His 248 1 2.39 2.16 2.12 2.22 Inhibition (%) of human FAS TE b 55 .46 ± 1 .45 c 52.90 ± 4. 34 c 55.53 ... subunit of b-conglycinin P13916 7 54. 18 7 54. 44 KNPQLR f (263–268) b subunit of b-conglycinin P259 74 1323.79 1323.72 EITPEKNPQLR f (42 4 43 4) a subunit of...

Ngày tải lên: 06/03/2014, 09:22

... using the quantity one v4.1 (Bio-Rad) acquisition software. Acquisition was carried out with a GelDoc camera (Bio-Rad) for the PCR products, or with a GS710-calibrated densitometer (Bio-Rad) for the ... promoter sites by interaction with some cofactors such as cell cycle regulators. The interaction of DLf with two response elements and the mutual dependency of both sites sug...

Ngày tải lên: 30/03/2014, 08:20

... found at the N-terminus of the human Cdc45 protein (NCBI NP 00 349 5). This is in accordance with the so called N-end-rule, where the presence of the N-ter- minal residue affects the half-life of the ... the feasibility of the Cdc45-specific antibody on normal tissue specimens and tumour entities and compare the Cdc45 signals with the classical proliferation markers...

Ngày tải lên: 19/02/2014, 00:20

... screening The yeast two-hybrid system with the full-length human ER protein as a bait was employed. The cloned cDNA of the human ER gene was inserted into the bait plasmid, pHybLex ⁄ Zeo in frame with ... SKAR by tandem mass spectrometry. The bipartite region of PDIP46 ⁄ SKAR interacting with ER comprising residues 2 74 42 1 encompasses the docking site for S6K1 within...

Ngày tải lên: 19/02/2014, 05:20

... mLÆmin )1 . The matrix was washed with 100 mL cold buffer with high ionic strength (0.1 M Tris, 1 M NaCl pH 7.5). The material was then equilibrated with the elution buffer (0.2 M NaH 2 PO 4 pH 7.5) ... recom- binant. Vitamin B 12 (cobalamin, Cbl) is the most complex of the vitamins [1]; it is a complicated system with three trans- porting proteins and several receptors...

Ngày tải lên: 21/02/2014, 00:20

... war in der britischen Politik Williams. Figure 1: F-structure associated with (1) and strings generated from it. Exp 1a Exp 1b Exp 2 Num. items 44 52 41 Avg. sent length 14. 4 12.1 9 .4 Table 2: ... for the items with 4 possible alternatives, over 70% of the time, the judges chose between only 2 of them. For the items with 5 possible alternatives, in 10% of those items...

Ngày tải lên: 22/02/2014, 02:20

... agreement with the value previously reported, $ 1 34 min )1 [41 ]. The difference is probably associated with the less pre- cise determination of enzyme active sites with the Bradford method than with cofactor ... sulfinate [ 74] . The spectra of KATII (Fig. 4A) and Tyr 142 fi Phe KATII (data not shown) in the presence of CSA exhibited a decrease in the intensity of the...

Ngày tải lên: 06/03/2014, 00:21

... reactions from the experimental thermograms without fitting to any particular model. The thermo- gram yields the overall enthalpy directly as the integral of the thermogram: DH ¼ Z C p dT ð1Þ The overall ... capacity changes are correlated with the exposure of hydrophobic surface areas [48 ,49 ] as well as increas- ing fluctuations among microstates associated with the less...

Ngày tải lên: 06/03/2014, 09:22

... 2009) doi:10.1111/j.1 742 -46 58.2009.0 746 3.x The 3¢-ends of human chromosomal DNA terminate in short single- stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance ... consistent with oral bio-avail- ability (although this in itself may not be an important goal). The three positive charges on the BRACO-19 molecule ar...

Ngày tải lên: 06/03/2014, 09:22