Báo cáo khoa học: Peptides from purified soybean b-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain pot

... between the indicated parameter with the FAS inhibitory potency (the lower the IC 50 value the higher the potency) of each peptide. C. Martinez-Villaluenga et al. b-conglycinin peptides inhibit fatty ... al. b-conglycinin peptides inhibit fatty acid synthase FEBS Journal 277 (2010) 1481–1493 ª 2010 The Authors Journal compilation ª 2010 FEBS 1493 Peptides...

Ngày tải lên: 06/03/2014, 09:22

... except for the KS site. The shape of this dimer is rather asymmetric, and hence the sizes of the catalytic chambers are significantly different from one another. This fact, together with the considerable ... weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379–2381. 11 Shu IW, Lindenberg DL, Mizuno TM, Roberts JL & Mobbs CV (2003) The fat...

Ngày tải lên: 16/03/2014, 06:20

... is mediated by protease inhibitors [3]. The inhibitors are thought to have coevolved with insect herbivory, and to function by blocking the digestive proteases in the larval gut, thereby limiting the ... clearly less flexible at the Ca position of the P2 residue than an amino acid. Inhibition of Helicoverpa trypsins by four plant protease inhibitors The effect of plant...

Ngày tải lên: 23/03/2014, 20:22

... and purified the protein without tags. We show that NblA from Anabaena sp. PCC 7120 is a mostly a-helical protein. The results from the thermally induced folding-unfolding experiments indicate the ... were obtained from fits over the whole boundary to the monomer-trimer model. The molecular mass parameter was kept constant at the value calculated from the sequence an...

Ngày tải lên: 08/03/2014, 10:20

... reduced by the presence of antimycin A, suggesting that the functional state of the mitochondria is somehow sensed by regulatory mechanisms. Perhaps the decreased levels of these enzymes, and other ... is retained in the nucleus in the presence of H 2 O 2 and thereby it interacts with the target genes [11,46,47]. This retention is dependent of the oxidation of Yap1 cyste...

Ngày tải lên: 16/03/2014, 14:20

... is assigned the value of . The next step executes the function. selects the arc pair with the highest arc score and performs the graph branch operation with the selected arc pair. The following ... maximize the score of the solution because the best solution is the maximum tree in the DF. 3.2 Graph Branch Algorithm The graph branch algorithm is obtained by de...

Ngày tải lên: 31/03/2014, 01:20

... Proposed catalytic mechanism for the reductive carboxylation of acetyl-CoA catalyzed by POR. The HE-TPP radical is illustrated on the basis of the model proposed by Barletta et al. [57] with the unpaired ... obtained in the present study, along with evidence available from the literature, we are able to propose the catalytic mechanism of the reductive carboxyla...

Ngày tải lên: 16/02/2014, 09:20

... round of immunodepletion (not shown). The interaction of this fraction with the antibodies may be prevented by the presence of partner(s) associated with the C-terminal region of PRiMA. In addition, ... terminating the synaptic transmission by hydrolyzing the neurotransmitter acetylcholine at the neuron-to-neuron synapses in the central nervous sys- tem and at the...

Ngày tải lên: 18/02/2014, 08:20

... for the T peptide and numbering starts at the first amino acid of the peptide. The six conserved aromatic amino acids of the WAT domain are indicated by ; the one nonconserved aromatic residue by ... intestinalis AChE catalytic subunits with the PRAD domain of ColQ indicates that the WAT domain of the C. intestinalis AChE is capable of organizing the sub- un...

Ngày tải lên: 18/02/2014, 17:20

... in the case of the full-length protein. However, compared with the pores made by com- plete Bax, the pores made by the Bax peptides are smaller and do not need the concerted action of tBid. These ... insertion into, the mitochondrial outer membrane [4–6]. The lat- ter process is promoted by other types of Bcl2 protein, exemplified by Bid, that share with the for...

Ngày tải lên: 19/02/2014, 07:20