Báo cáo khoa học: Amyloid oligomers: diffuse oligomer-based transmission of yeast prions ppt

... oligomers: diffuse oligomer-based transmission of yeast prions Hideki Taguchi and Shigeko Kawai-Noma Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, ... to the cure of [PSI + ]. Overexpression of Sup35 in the cells often induces the formation of visible, rod-like aggregates. H. Taguchi and S. Kawai-Noma Oligomer-base...

Ngày tải lên: 06/03/2014, 09:22

... mecha- nism of neurodegeneration induced by Alzheimer’s beta -amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res Bull 53, 389–397. 54 Soto C (2003) Unfolding the role of ... 1072–1078. Formation of toxic Ab oligomers M. Sakono and T. Zako 1358 FEBS Journal 277 (2010) 1348–1358 ª 2010 The Authors Journal compilation ª 2010 FEBS MINIREVIEW Amyloid ol...

Ngày tải lên: 06/03/2014, 09:22

... potential toxicity of mutant proteins, such as SOD1, detailed spatiotemporal examination of the polyubiquitination of mutant SOD1 using FRET may be useful for inves- tigating the details of the role of the ... these diseases, inclusions of the mutant proteins are found in the neuronal cells of patients and the accumulation of misfolded proteins is considered to be a primary ca...

Ngày tải lên: 06/03/2014, 09:22

... MINIREVIEW Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states Mikael Lindgren 1 and Per Hammarstro ¨ m 2 1 Department of Physics, Norwegian University of Science ... control the assembly and toxicity of amyloid oligomers. To clarify the mechanism of fibril formation and the relation of the amyloidogenesis processes to numerous amyloid diseases...

Ngày tải lên: 06/03/2014, 09:22

... validation of the two-state reversible interpretation of the denaturation of the [TetR– Tc] complex was obtained using a vant’Hoff analysis of the CD data. Taking into account that the intensity of CD signals ... concentration of 0.4 mgÆmL )1 and scan rate of 1 KÆmin )1 , T max is 60.4 °C. The denaturation temperature, T max , of the complex of TetR with Tc is 70.4 °C, measu...

Ngày tải lên: 20/02/2014, 02:21

... the problem of indirect associations, illus- trated in Figure 1. The sequences of u's and v's represent corresponding regions of a bitext. If uk and vk co-occur much more often than ... frequency of a word type pair is simply the number of times the pair co-occurs in the corpus. However, n(u) = ~-~v n(u.v), which is not the same as the frequency of u, because eac...

Ngày tải lên: 22/02/2014, 03:20

... course of the N/V stress shift, and can thus be seen as pos- sible sources of the diachronic dynamics of N/V pairs. 5 5 This type of assumption is necessary for any hypothesis about the sources of ... analyze the dynamics of 5 dynamical systems models of linguistic populations, each derived from a model of learning by individuals. We compare each model’s dy- namics to a set o...

Ngày tải lên: 17/03/2014, 00:20

... functional analysis of the six cysteines in yeast Erv1p was the major goal of this paper. All three pairs of cysteines in Erv1p are indispensable for in vivo activity The six cysteines of yeast Erv1p ... introduction of a polar group probably interferes with binding of the adenine portion of the FAD that is normally attached to this region of the protein. Conse- quently, t...

Ngày tải lên: 17/03/2014, 10:20

... antiserum that recognizes, with comparable efficiencies, both of the yeast and both of the human isoforms of Hsp90 indi- cated that the levels of Hsp90 expression in strains PP30[pHSC82b], PP30[pHSP82], ... in yeast [18]. ERK5 is the human ortholog of the yeast Slt2p cell integrity MAP kinase (also an Hsp90 client); heter- ologous expression of ERK5 in yeast completely res-...

Ngày tải lên: 23/03/2014, 07:20

... to evaluate the complexity of the algorithms as a function of the size of the grammar, we assume that I V I and I GI are of the same order of magnitude n. Step 1 of the algorithm corresponds ... tractability and the quality of the lexicalization. The Problem of the Lexiealization of a Grammar Given a lexicalized grammar, this part describes the problem of the opt...

Ngày tải lên: 23/03/2014, 20:21