Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot

... have shown that the costimulatory activity of CD26 involves the ligand-binding domain [124,125]. A recent in vivo study using a DPIV-selective inhibitor in DPIV gko mice has further shown independence ... [77]. DPIV enzyme activity is effective on a number of chemokines in vitro (Table 2). DPIV in cell biology A number of DPIV-binding proteins have been identi- fied, including...

Ngày tải lên: 06/03/2014, 09:22

... 670–711) and not in the DNA-binding domain (Fig. 6). These results provide another convincing example highlighting the AB Fig. 7. The glycosylated t runcated forms of HIC1 a re unable to bind their ... O-GlcNAc residues did not interfere directly or indirectly with the DNA-binding activity, but their involvement in protein stability or in protein–protein interaction had to be...

Ngày tải lên: 30/03/2014, 15:20

... in their daily work. The system offers facilities to assist linguists and internet users as they search for relevant material, and then clas- sify and annotate this material. 1 Introduction There's ... support linguists in their daily work. The system offers facilities to assist linguists and inter- net users as they search for relevant material, and then classify and...

Ngày tải lên: 31/03/2014, 20:20

... matrix and cell patho- gen interactions by binding to distinct, but overlapping, Table 2. Selectin, integrin and GPCR antagonists in clinical and preclinical studies. COPD, chronic obstructive pulmonary ... to transport the peptide across the cell membrane and tethers the pepducin to the inner leaflet of the lipid bilayer in molecular proximity to the intracellular l...

Ngày tải lên: 07/03/2014, 12:20

... CeMT-2 is only induced in intestinal cells in the presence of cadmium, but CeMT-1 is also constitutively active in three cells of the lower pharyngeal bulb [24]. These studies provided the first evidence ... to the wild-type strain. Both CeMT-1 and CeMT-2 are important in maintaining physiological zinc levels Under control (non-metal-supplemented) conditions in the wild-t...

Ngày tải lên: 16/02/2014, 15:20

... elevated in human cancer cells [81,82], the HSE-binding activity of HSF1 might be higher in cancer cells than in normal cells. Even so, the HSE- binding activity is robustly induced in response ... mechanisms for cell proliferation and survival in cancer cells and in yeast cells. Is the HSF1 in cancer cells activated? As HSF1 expression, which is correlated w...

Ngày tải lên: 18/02/2014, 04:20

... for the identification of the HABPs interacting with U937 and A549 cells (in this case), their binding dissociation constants, their critical binding residues and their role in cell invasion inhibition, ... well as the characterization of the high-activity binding peptide (HABP) involved in the binding to and invasion of monocytes (U937) and type II alveolar epithelial...

Ngày tải lên: 18/02/2014, 16:20

... increase the activity of aB-crystallin against DTT-induced precipi- tation of insulin at intermediate and high concentra- tions, and it also increased the activity of aB-crystallin in preventing the ... no in uence of the additive on the chaperone activity of aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is inde- pendent and...

Ngày tải lên: 18/02/2014, 16:20

... the nuclear periphery in two patient cell lines. Interestingly, the lamin A mutation in these two cell lines was within a DNA ⁄ chromatin binding domain [35]. Further, we have found that in cells ... determining and supporting the position of the nucleus in the cell [62,63]. Now, the recent identification of an interaction between the outer nuclear membrane protei...

Ngày tải lên: 19/02/2014, 02:20

... (rotation angle ‘r’) and variation of the inclination (inclination angle ‘i’) with respect to the plane of the membrane (parallel to the xy plane). Cter and Nter are the C-terminal and N-terminal structural ... pancre- atic RNase A, the superfamily prototype, has interested and intrigued investigators. Their ribonucleolytic activity is essential for their cytotoxic action,...

Ngày tải lên: 19/02/2014, 06:20