Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot

... in human disease FEBS Journal 277 (2010) 841–855 ª 2010 ICGEB Trieste (Italy) Journal compilation ª 2010 FEBS 855 MINIREVIEW Alternative splicing: role of pseudoexons in human disease and potential ... the development of novel splicing-based therapeutic agents to treat HIV-1 infections [73]; and new methods in the global analysis of alternative splicing p...

Ngày tải lên: 06/03/2014, 09:22

... further understanding of infection, spread and dissemination through splicing regulation. Such stud- ies coupled with the testing of splicing inhibitors should help the develop- ment of new therapeutic ... and to site A3 inhibition [36]. Enzymatic and chemical probing revealed the occurrence of several SC35 and SRp40 binding sites in SLS3 and in agreement with the stro...

Ngày tải lên: 06/03/2014, 09:22

... concen- trations (5 and 10 mm)ofMg 2+ inhibited the DNA cleavage activity (Fig. 4C, lane 4 and 5) and weak inhi- bition was observed even in 1 mm of Mg 2+ (compare lane 2 and 3 in Fig. 4C), indicating a different ... caspase-8- and caspase-9- like activities, which appear to be involved in the final resorption of the parental macronucleus during PND in T. thermophila, an...

Ngày tải lên: 20/02/2014, 03:20

... field for the investigation of the ele- ments involved in splicing regulation and the integra- tion of all these approaches will give us the best chance of finally understanding the splicing mechanism itself. An ... altering the essential protein func- tion are produced. In this review we briefly describe the current under- standing in the field and discuss emerging directions in...

Ngày tải lên: 06/03/2014, 09:22

... the MuvB proteins Lin-37, Lin-52, Lin-54 and chromatin- associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48. Furthermore, A-Myb and B-Myb were present in immunoprecipitations for Lin-9, Lin-37 and Lin-54 [90,92]. ... repression of genes, such as cyclin A and cyclin B1, in dividing cells [92]. Furthermore, depletion of Lin-9 and B-Myb in p53 ) ⁄ ) MEFs caused lowered expression...

Ngày tải lên: 16/02/2014, 09:20

... expression patterns of FOX1 and -2. Analysis of breast and ovarian cancer using an RT- PCR panel of alternative splicing events indicated that one-third of cases of increased exon skipping in cancer were ... cross-linking and immunoprecipitation; CELF, CUGBP and ETR3 like family (of RNA binding proteins); CUGBP, CUG binding protein; miRNA, micro-RNA; RNP, ribonucleoprot...

Ngày tải lên: 06/03/2014, 09:22

... subsampling is that we use our entire training corpus, and in so doing compromise between min- imizing errors from data sparsity and accommodat- ing domain shifts to the extent possible. 3 A Growing ... in- domain (NYT00+01) and out -of- domain (AFP02+05+06) training corpora, for two meth- ods of closing the vocabulary. in each to optimize tune-set perplexity. For evaluation, we...

Ngày tải lên: 20/02/2014, 04:20

... glosses) grammar in tandem with the treebank, as part of our research into natural language understanding. Treebanking the output of the parser allows us to immediately identify problems in the grammar, and ... the use of similarity and/ or se- mantic class based back-offs for parsing and gen- eration with both symbolic grammars and statisti- cal models. In order to make th...

Ngày tải lên: 20/02/2014, 12:20

... the beginning and ending of the character string to be recognized and translated. In Figure 3, circles on both ends of the string denote the user specified points. All the lo- cations of characters ... contains many signboards whose phrases provide useful information. These include destina- tions and notices in transportation facilities, names of buildings and shops, explan...

Ngày tải lên: 20/02/2014, 15:20

... consists of 24 computer-mediated dialogues 1 in which two participants collaborate on a simple task of buying furniture for the living and dining rooms of a house (a variant of the task in (Walker, ... corpus, and the issue of tracking agreement. Next we describe our coding scheme and our intercoder reliability outcomes. Last we report our findings .on tracking agre...

Ngày tải lên: 20/02/2014, 18:20