Báo cáo khoa học: Human telomeric G-quadruplex: structures of DNA and RNA sequences ppt

... [25–54]. Long human telomeric DNA and RNA sequences The next step toward understanding the structure of the ‘real’ telomeres is to address the question on the structure of long human telomeric DNA sequences [27,37,67,68]. ... The problem is the same for the long human telomeric RNA sequences [66,69]. Data [37,67,69] suggested that the structures of long hu...

Ngày tải lên: 06/03/2014, 09:22

... [17] offers the most recent discus- sion of the variety of G-quadruplex structures formed by human telomeric DNA and RNA. Na + and K + cations appear to dictate the unimolecular folding of the telomeric ... new mod- els of the human telomere d[AGGG(TTAGGG) 3 ]in K + solution. Bioorg Med Chem 14, 5584–5591. 17 Phan AT (2009) Human telomeric G-quadruplex: struc- t...

Ngày tải lên: 06/03/2014, 09:22

... proteins and induce the single-stranded DNA to form quadruplex– ligand complexes are, in effect, able to expose these 3¢-ends, which results in the activation of a DNA damage response and selective ... Journal compilation ª 2009 FEBS consequence of the end-replication effect, and once telomeric DNA is at a critically short length, cells enter p53 and Rb-dependent replicati...

Ngày tải lên: 06/03/2014, 09:22

... (product of PRSS1, OMIM 276000), anionic trypsinogen (product of PRSS2, MIM 601564), and mesotrypsinogen (product of PRSS3)(forareviewon human trypsinogen genes and proteins see [1] and references therein). ... from the 120 min lanes of panel B, demonstrating the resolution of the four human trypsin(ogen) species in the gel. Tg, trypsinogen; bands A and B correspond to t...

Ngày tải lên: 17/03/2014, 03:20

... (i.e. labelled rooted trees) and projective dependency trees are counted by sequences A000169 and A006013 (offset 1), respectively, in the On-Line Encyclopedia of Sequences (Sloane, 2007). 608 ditionally, ... properties of individual non-projective edges (cf. Definition 3); and they take into account levels of nodes in dependency trees explicitly. None of the constraints and...

Ngày tải lên: 23/03/2014, 18:20

... seven) and strand b3by four residues (five versus nine) (Fig. 1 and Table S1). In addition, the loops between a1 and b2; a3 and b4; and a4 and b5 are shortened compared to dsFld. Analysis of 199 ... crystal structures of NrdI from Bacillus anthracis, the causative agent of anthrax, in the oxidized and semiquinone forms, at resolutions of 0.96 and 1.4 A ˚ , respec- tiv...

Ngày tải lên: 29/03/2014, 21:20

... Takahashi, T., Sandhoff, K. & Desnick, R.J. (1991) Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. ... mutagenesis of the potential glycosylation sites and subsequent expression of mutated cDNA constructs indicated that at least five of them are used in vivo [7]. Ceramide and sphi...

Ngày tải lên: 31/03/2014, 07:20

... Titov and Ryan McDonald. 2008. A joint model of text and aspect ratings for sentiment summarization. In Proceedings of the 46th Annual Meeting of the As- sociation of Computational Linguistics: Human ... for each edge of the graph. 6: Refine the scores  S 1 and  S 3 of the k 2 sentiment and topic word candidates using Eqs. (5) and (6) iteratively. 7: Select k 1 new se...

Ngày tải lên: 19/02/2014, 19:20

... features of the LPO and MPO catalytic cycle, such as the existence of Compound I and Compound II isomers and the identification of their spectroscopic properties. After addressing each of these ... each of these questions, we will propose a new hypothesis that describes an integrated vision of the catalytic mechanism of MPO and LPO. A brief survey of the absorption feat...

Ngày tải lên: 20/02/2014, 02:21

... performances of the word aligners with available data and available alignment models. One possible solution is to use the boosting method (Freund and Schapire, 1996), which is one of the ensemble ... distribution of the labeled data. The second method changes the distribution of both the la- beled data and the unlabeled data during training. Experimental results show that...

Ngày tải lên: 08/03/2014, 02:21