RNA Interference Technology FROM BASIC SCIENCE TO DRUG DEVELOPMENT ppt

... dsamarsky@oligo.com Brad Scherer, PhD. BD Biosciences Clontech 1020 East Meadow Circle Palo Alto, CA 94303 USA RNA INTERFERENCE TECHNOLOGY RNA Interference (RNAi) technology has rapidly become one of ... information on RNAi and will be useful to experts on RNAi as well as investigators in many fields of research who may be interested in using RNAi to explore problems they are s...

Ngày tải lên: 06/03/2014, 09:21

... Psychology, Washington State University, Spokane, Washington William W. Stoops, PhD, Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky Linda ... ways to produce the drug, local production remains low relative to historic highs. This is a bright spot in the “war against methamphetamine,” as manufacture poses very serious risks to th...

Ngày tải lên: 06/03/2014, 09:21

... School; Consultant Hepatologist Beth Israel Deaconess Medical Center Boston, MA, USA Nazia Selzner MD PhD Transplant Hepatology Fellow Multiorgan Transplant Program Toronto General Hospital Toronto, ON, Canada David ... and that attaching to the duodenum, the hepatoduodenal ligament. In addition, peritoneal folds can extend from the liver to the right colic flexure. This basic descript...

Ngày tải lên: 06/03/2014, 09:21

... functional genomic research. It is therefore interesting to * Author to whom correspondence should be addressed. MicroRNAs: From Basic Science to Disease Biology, ed. Krishnarao Appasani. Published ... turned out to be spectacularly true and this book deals with one class of novel RNAs, the microRNAs (miRNAs). The task now is to elucidate the nature and function of all these n...

Ngày tải lên: 06/03/2014, 09:21

... within the cytoplasm and translocates to the nucleus where it binds to either one of two transcription factor families, transcription factor (TCF) and lymphoid enhancer binding fac- tor (LEF)1. ... number of regulatory signalling pathways are repor ted to be involved in normal mammary SCs including the Hedgehog, Notch, leukaemia inhibitory factor (LIF), transforming growth facto-β(TGF-β...

Ngày tải lên: 15/03/2014, 09:20

... 1998a). Growth factors Vascular growth factors are potent chemoattractants and mitogens. Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996). Despite this, opening of Ca 2+ channels causes [Ca 2+ ] i to rise to micromolar l...

Ngày tải lên: 22/03/2014, 20:21

... µm Localization in epidermis Up to stratum spinosum Up to granular layer Receptors (receptor for growth factors, other receptors) trkA, p75, e.g. Histamine receptor, Trp-group c-RET, binding of ... J Invest Dermatol 47:193–204 8. Breathnach AS (1977) Electron microscopy of cutaneous nerves and receptors. J Invest Dermatol 69:8–26 9. Burnstock G (1977) Autonomic neuroeffector junctions...

Ngày tải lên: 22/03/2014, 21:20

... cyanogen bromide peptides. Topological proteomics A technology which analyzes proteins on a single cell lev el; study of the toponome. Transcriptomics The total RNA transcripts produced by a ... Turning tomorrow’s medicine into today’s reality, Curr. Drug Disc., 23, September 2002. 4. Picard, F.J. and Bergeron, M.G., Rapid molecular theranostics in infectious diseases, Drug Disc. Tod...

Ngày tải lên: 22/03/2014, 21:20