... BiochemistryUniversity of BristolThe School of Medical SciencesUniversity Walk, Bristol BS8 1TDUKE-mail: p.kuwabara@bristol.ac.ukEric Lader, PhD.QIAGEN, Inc.19300 Germantown RdGermantown, MD 20874USAE-mail: ... diseases.It is too early to say how successful RNAi therapy will be. However, it is clear thatRNAi is a powerful tool that has revolutionized basic research and that the abilityof RNAi to down-regulate ... of histone H3 lysine 27 methylation in polycomb-groupsilencing. Science, 298, 1039–1043.Carrington, J. C. and Ambros, V. (2003). Role of microRNAs in plant and animal develop-ment. Science, ...