Báo cáo khoa học: Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies pot

... MINIREVIEW Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies Stavros J. Hamodrakas Department of ... other parame- ters are calculated and reported, such as the average a4v in each hot-spot, the area of the aggregation pro- file above t...

Ngày tải lên: 06/03/2014, 00:20

... bond-containing proteins [8]. The Ventura group and others have made considerable progress in studying three model proteins from human pests, namely the car- boxypeptidase inhibitors from the leech and from ... their coat proteins, and A. Land (Utr- echt, The Netherlands) described how complex this is Protein folding and disulfide formation A. M. Benham 6906 FEBS Jour...

Ngày tải lên: 29/03/2014, 22:21

... referenced in the same sentence. Other information can be derived from the mood and aspect of the verb, from the lexical category which the verb is a member of and, more generally, from several ... identify the errors, if any, present in the former and to formulate some hypotheses about their causes. On the basis of these hy- potheses, the Tutor select...

Ngày tải lên: 01/04/2014, 00:20

... in the brain and further displays a number of structural features not present in the other members of the APP superfamily, such as the absence of the exon encoding the KPI domain and the lack of ... in the appearance of the APLP1 and APLP2 gene families. The fact that both mammals and Xenopus contain APP and APLP2 proteins suggests that the first gene...

Ngày tải lên: 16/03/2014, 16:20

... potentials of the surface of the CPR FMN domain and of a model of the FMN domain of human MSR. Fig. S3. Electrostatic potentials of the surface of the hMS AD. Table S1. Sequences of oligonucleotides ... inset). The absorption spectrum of the purified enzyme was typical of the hydroxycobalamin form of the enzyme (Fig. 2). The recovery of the activ...

Ngày tải lên: 18/02/2014, 08:20

... of the 53 kDa spot (5.3) was identical to a pI value calcu- lated from the amino acid sequence of GmPDIL-3a, and the isoelectric point of the 57 kDa spot (5.1) was consistent with that from the ... organelle and membrane proteins are synthe- sized and folded with the assistance of molecular chap- erones and other folding factors in the endoplasmic reticulum (...

Ngày tải lên: 18/02/2014, 11:20

... suggesting the absence of CK2 sites N-terminal of position 402 in the catalytic domain and the presence of several phosphorylation sites for CK2 in the C-terminal portion of Rio1p, one (or more) of them ... previ- ous observation that either depletion of Rio1p in the cell or the use of a weak D244E mutant allele leads to increased loss of minichromosomes and to...

Ngày tải lên: 18/02/2014, 16:20

... for the proteins with the complete arrangement. To take into account the variability of the length of the complete domain, the length of the N-terminal fragment was definned as the length of the amino ... the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein and t...

Ngày tải lên: 19/02/2014, 07:20

... with the higher inhibitory activity of the cEL peptide and the very low inhibitory activity of the cYT peptide compared to other peptides. The flanking residue of the b-turn, i.e. Tyr3 of the cVY peptide ... solution and clo- sely mimic the b-turn s tructure of the surface epitopes of the CD2 protein. Docking studies of CD2 peptides and CD58 protein r...

Ngày tải lên: 19/02/2014, 13:20

... GdmCl on the secondary structure of the protein. In the far-UV region, the CD spectra of the FprA show the presence of substantial a-helical conformation [15]. Fig. 1C sum- marizes the effect of increasing ... infor- mation on the structural and dynamic properties of the protein [16]. The FprA molecule contains five tryp- tophan residues at positions 46, 131,...

Ngày tải lên: 19/02/2014, 16:20