Báo cáo khoa học: Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice pot

... compilation ª 2011 FEBS 3129 Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice Eleni A. Karavia 1 , Dionysios J. Papachristou 2 , Ioanna ... develops Abbreviations apoE, apolipoprotein E; apoE ) ⁄ ) , apoE deficient; apoE3 knock -in mice, mice containing a targeted replacement of the mouse ap...

Ngày tải lên: 05/03/2014, 23:20

... gastrin–ApoTf complex, EDTA was injected into the BIAcore to chelate any available iron. As soon as the EDTA was injected, the association between gastrins and ApoTf was disrupted, indicating that ... interaction in iron homeostasis. In the present work, the interaction between gastrins and transferrin has been characterized by surface plasmon resonance and covalent crosslinking. First,...

Ngày tải lên: 07/03/2014, 02:20

... be a useful diagnostic marker for renal injury associated with diabetes or hypertension, because the urinary and plasma concentrations are increased in patients with these diseases. How- ever, ... size markers are shown on the left. (B) Schematic representation of GST-fusion proteins containing a series of amino-terminus-truncated human L-PGDS. The amino-terminal amino acid residue of...

Ngày tải lên: 30/03/2014, 01:20

... functions also serve as paracrine signalling molecules upon unconventional release into the extracellular space? The answers to these questions are of exceptional interest as the cargo proteins secreted ... is mediated in a temperature-sensitive manner by proteina- ceous machineries that are insensitive to brefeldin A. Leishmania HASPB Another quite remarkable example of nonclassical pr...

Ngày tải lên: 17/03/2014, 03:20

... A ) indicating the first mannose addition were detected as intermediates (Fig. 6A) . To examine the intermediate structures, the fraction containing products A and A was collected and treated with ... (5¢-CAAGAGGTGGTATTTACTCAGCTATGGATA CTATGCTTTTGAA-3¢) and D18 8A- RV (5¢-TTCAAAAGC ATAGTATCCATAGCTGAGTAAATACCACCTCTTG-3¢), and the pPICZaA-ScOCH1 as a template. The both D18 8A mutant and w...

Ngày tải lên: 23/03/2014, 10:20

... experimentally [11]. Notably, the archaeon Methanosarcina mazei has t wo lon genes, an ar chaeal-type lon gene containing two transmem- brane helices and a bacterial-type lon gene including an N-terminal ... ATPase domain. Noncanonical Lon proteases are also found in bacteria and viruses (Fig. 1B,C). A separate study failed to detect the ATP-binding region in the archaeal Lon protea...

Ngày tải lên: 30/03/2014, 15:20

... For instance, in the later stages of neurodegenerative diseases the neuronal damage may interfere with the neuroglial interactions, lowering GIF production and secretion in reactive astrocytes. ... GIF AD is a neurodegenerative disease that leads to severe dementia and ultimately death. The pathological hallmarks of the disease are intracellular neurofibril- lary tangles, dystrophic...

Ngày tải lên: 16/02/2014, 15:20

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Ngày tải lên: 17/02/2014, 17:20

... Samples were taken to measure the whole-cell protein concentration, fermentative capacity, mRNA levels and the capacities of the glycolytic and fermentative enzymes. After all samples had been taken, ... experiments, the steady-state fluxes were estimated. Averages and SD were calculated separately for the numerator and the denominator of Eqn (5). Based on the SD of the numerator and the den...

Ngày tải lên: 18/02/2014, 06:20

... whether the observed IL-1b mRNA changes are due to a decrease in transcription or an increased degradation rate, we performed experi- ments with actinomycin D. HepG2 cells stably overexpressing ... the MCPIP gene was observed in leukocytes, with intermediate levels in heart and placenta, and the lowest levels in spleen, kid- ney, liver and lung. The transcript was not detectable...

Ngày tải lên: 18/02/2014, 14:20