Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt

... preparation. Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38. In other words, the presence of CD38 is mandatory for the ... release of ATP but not the release of ATP evoked by action potential firings. The enhancing effect of cADPR on spontaneous release of...

Ngày tải lên: 05/03/2014, 23:20

... bridge to the increase in the Gibbs free energy of activation of unfolding under native conditions. Using the linear extrapolation model [27], the rate constant for the unfolding of G8C ⁄ N60C in the ... the intermediate in the unfolding. Calcium ions are the main contributory factor to enzyme stability The binding of calcium ions seems to be the main...

Ngày tải lên: 19/02/2014, 17:20

... cluster. Adding new words into the lexicon, on the other hand, offers explicit reinforcement in PP of the reference char- acters. Such reinforcement offers the main positive boosting for the PP of reference ... probability of the entire edge over the segments – P (e i |A) ≈ n  P (e|A). The basic meaning of Equation (1) is to calculate the ratio of the paths...

Ngày tải lên: 20/02/2014, 07:20

... production of these morphemes in an attempt to determine in which way these morphemes are related to the words. Are they unified with the word in all instances or only in certain contexts? Adapting ... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The...

Ngày tải lên: 21/02/2014, 20:20

... help them during the design phase, being able to reuse workflows (or parts of them) and thus avoiding reinveinting the wheel. 4 Using the tools to work with NLP All the aforementioned tools were installed, ... needs to be adapted to the TO, this way we can interconnect the different tools in the platform regardless of their original input/output formats. We have ad...

Ngày tải lên: 22/02/2014, 03:20

... cargo trafficking to the lysosomal pathway is the ubiquitina- tion of cargo proteins. The UIM domain of Hrs has been shown to bind ubiquitin in vitro [9,11,14] and to facilitate the sorting of several ... specifically recognized by the UIM domain of Hrs (Fig. 3 and Table 1). The specific binding of the identified proteins to the Hrs UIM domain suggests that the...

Ngày tải lên: 07/03/2014, 03:20

... multidomain members of the RNase III fam- ily that are responsible for processing long dsRNAs into effector siRNAs. Human Dicer contains a single PAZ domain, a single dsRNA-binding domain, and ATPase ... sequences homologous to those of the targeted RNAs caused knockout phenotypes in Adiantum gametophytes, and the lack of a silencing effect when dsDNA corre- sponded to the...

Ngày tải lên: 16/03/2014, 02:20

... is the thioesterase involved in the release of AA inside the mitochondria. Our model explaining how AA is released into the mitochondria also supports the concept that the select- ive actions of ... that the effect of AA-CoA is due to its con- version to AA into the mitochondria. If this is the case, inhibition of AA-CoA uptake into the mitochon- dria shoul...

Ngày tải lên: 16/03/2014, 12:20

... membrane rich in choles- terol to the destabilizing effects of the aggregates, and to the early upregulation of Bcl-2, possibly counteract- ing the initial formation of MAC in the outer mito- chondrial ... [23]. Under these conditions, other mitochondrial proteins, inclu- ding AIF can be released [24]. The early apoptotic steps in either cell line exposed to the...

Ngày tải lên: 16/03/2014, 13:20

... However, rather than splitting the data into separate training and test sets, they evaluate the models in an extra- polation setting, where the parameters of the model are estimated on a subset of the ... and all words were converted to lowercase). Each of these sam- ples was then split into a training set of 1 million to- kens (the training size N 0 ) and a test set...

Ngày tải lên: 17/03/2014, 04:20