Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt

... preparation. Of particular importance is the ﬁnding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38. In other words, the presence of CD38 is mandatoryfor the ... release of ATP but not the release of ATP evokedby action potential ﬁrings. The enhancing effect of cADPR on spontaneous release of ATP was: (a) unaf-fected by inhibition of P2 purinoreceptors; ... responses to ATP were potentiated by cADPR, suggesting that the two adenine nucleotides may work in synergy to maintain the restingtone of the bladder. In conclusion, extracellular cADPR enhances the spontaneous...

Tài liệu Báo cáo khoa học: An engineered disulﬁde bridge mimics the effect of calcium to protect neutral protease against local unfolding docx

... bridge to the increase in the Gibbs free energy of activation of unfolding undernative conditions. Using the linear extrapolation model[27], the rate constant for the unfolding of G8C ⁄ N60C in the ... the intermediate in the unfolding.Calcium ions are the main contributory factor to enzyme stability The binding of calcium ions seems to be the mainsource of stabilization of the neutral protease ... related to the position of the introduced disulﬁde bridge thatis located in the vicinity of calcium binding-site III(Fig. 1). To assign the contribution of bound calciumions at calcium binding-site...

Tài liệu Báo cáo khoa học: "Discriminative Lexicon Adaptation for Improved Character Accuracy – A New Direction in Chinese Language Modeling" pptx

... cluster. Adding newwords into the lexicon, on the other hand, offersexplicit reinforcement in PP of the reference char-acters. Such reinforcement offers the main positiveboosting for the PP of reference ... probability of the entire edge over the segments – P (ei|A) ≈nP (e|A). The basic meaning of Equation (1) is to calculate the ratio of the paths going through aspeciﬁc edge divided by the total ... by the intuition. However, the inter-connectivity between all sub-edges and the proper weights of them are not easy to be han-dled well. Here we constrain the inter-connectivity of sub-edges to...

Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx

... production of these morphemes in an attempt to determine in which way these morphemes are related to the words. Are they unified with the word in all instances or only in certain contexts? Adapting ... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... linguistic results. Finally, to further illustrate the problems encountered in determining the phonetic repre- sentation, examples of the implications of de- ciding to represent the word for water,...

Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx

... help them during the designphase, being able to reuse workﬂows (or parts of them) and thus avoiding reinveinting the wheel.4 Using the tools to work with NLPAll the aforementioned tools were installed, ... needs to be adapted to the TO, this way we can interconnect the differenttools in the platform regardless of their originalinput/output formats.We have adopted for TO the XML Corpus En-coding ... installed. The paradigm changes considerably with WSs,as in this case only the WSP needs to have a deepknowledge of the installation and maintenance of the tool, thus allowing all the other users to...

Báo cáo khoa học: Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes ppt

... cargotrafﬁcking to the lysosomal pathway is the ubiquitina-tion of cargo proteins. The UIM domain of Hrs hasbeen shown to bind ubiquitin in vitro [9,11,14] and to facilitate the sorting of several ... speciﬁcallyrecognized by the UIM domain of Hrs (Fig. 3 andTable 1). The speciﬁc binding of the identiﬁed proteins to the Hrs UIM domain suggests that these proteinsmay be ubiquitinated. In support of this notion, ... proteins were identiﬁed using both of the predictive hmmtop servers [77,78].Classiﬁcation of Hrs UIM-interacting proteins The identiﬁed Hrs UIM-interacting proteins were classiﬁedaccording to their...

Báo cáo khoa học: A new and efﬁcient method for inhibition of RNA viruses by DNA interference pptx

... multidomain members of the RNase III fam-ily that are responsible for processing long dsRNAsinto effector siRNAs. Human Dicer contains a singlePAZ domain, a single dsRNA-binding domain, andATPase ... sequenceshomologous to those of the targeted RNAs causedknockout phenotypes in Adiantum gametophytes, and the lack of a silencing effect when dsDNA corre-sponded to the intron sequence of the target ... of sequence-speciﬁc inhibition of viral RNA both in tobacco plants and in HeLa cells. Furthermore, Dicerhas been shown to be capable of DNA cleavage, whichsuggests that the silencing of viral RNA was due to...

Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf

... is the thioesterase involved in the release of AA inside the mitochondria.Our model explaining how AA is released into the mitochondria also supports the concept that the select-ive actions of ... that the effect of AA-CoA is due to its con-version to AA into the mitochondria. If this is the case, inhibition of AA-CoA uptake into the mitochon-dria should inhibit steroid synthesis. Indeed, ... explain the mechanism bywhich in these situations there is a remaining 20% of steroid synthesis, due to the direct effect of AA ⁄AA-CoA produced within the mitochondria by the action of ACS4...

Báo cáo khoa học: Differing molecular mechanisms appear to underlie early toxicity of preﬁbrillar HypF-N aggregates to different cell types potx

... membrane rich in choles-terol to the destabilizing effects of the aggregates, and to the early upregulation of Bcl-2, possibly counteract-ing the initial formation of MAC in the outer mito-chondrial ... [23]. Underthese conditions, other mitochondrial proteins, inclu-ding AIF can be released [24]. The early apoptoticsteps in either cell line exposed to the toxic HypF-Naggregates were investigated ... MAC, the proposed channel allow-ing cytochrome c to translocate to the cytosol [43],thus explaining the complete recovery in mitochondrialfunction, which is also supported by the recovery in ATP...

Báo cáo khoa học: "Words and Echoes: Assessing and Mitigating the Non-Randomness Problem in Word Frequency Distribution Modeling" ppt

... However,rather than splitting the data into separate trainingand test sets, they evaluate the models in an extra-polation setting, where the parameters of the modelare estimated on a subset of the ... and all wordswere converted to lowercase). Each of these sam-ples was then split into a training set of 1 million to- kens (the training size N0) and a test set of 3 million4See www.natcorp.ox.ac.uk, ... fortraining precede, chronologically, the data one wants to generalize to. We estimate parameters of the ZM, fZM andGIGP models on each training set, using the zipfRtoolkit.5 The models are then...

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