... deficiency in the striatum of patients withParkinson’s disease and the subsequent introduction of levodopa as a dramatically effective therapy of this hithertodevastating illness. Since then the therapeutic ... R., Cristina, S. et al. (2003) Double-blindplacebo controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkin-sonism. Movement Disorders, ... 413.Zanettini, R., Antonini, A., Gatto, G. et al. (2007) Valvular heart disease and the use of dopamine agonists for Parkinson’s disease. The New England Journal of Medicine, 356 (1), 39 46.90 PARKINSON’S...