Hydroxyurea for the Treatment of Sickle Cell Disease docx

... Labeling The current labeled dosing of hydroxyurea for sickle cell disease calls for the administration of an initial dose of 15 mg/kg/day in the form of a single dose, with monitoring of the patient’s ... development at the time of the review. We applied evidence grades to the bodies of evidence about the efficacy and/or effectiveness of hydroxyurea for the treatment of sickle cell disease in one ... efficacy of hydroxyurea in sickle cell disease, there is clearly a need for further research on the barriers to the use of this drug. These studies should aim to identify barriers at the level of the...

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Tài liệu THE MANAGEMENT OF SICKLE CELL DISEASE ppt

... stroke, in the children randomized to the transfusionarm. At the end of the trial, all participantswere offered periodic transfusion therapy. The main side effects of the transfusion therapywere ... completely. Therefore, it is not recommended. The usual treatment for pediatric patients in the acute stage of ischemic stroke is hydrationwith transfusion, although there are no con-trolled treatment ... children with sickle cell disease. N Engl J Med 2000;342:83-9.24. Moser FG, Miller ST, Bello JA, et al. The spectrum of brain MR abnormalities in sickle cell disease: a report from the cooperative...

Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

... cost. There is no cure for AD,and the development of effective therapeutic strategiesis hampered by a paucity of information on the biolo-gical mechanisms underlying the disease. The severity of ... have the potential to ameliorate several of the dysfunctional events characteristic of Alzheimer’s disease. Metal-basedtherapeutics have already provided promising results for the treatment of Alzheimer’s ... Cu out of the cell. However, once intracellular Cu levels become toolow, possibly because of the aberrant increase in Abproduction consistent with AD, the antioxidant capa-city of the cell may...

Tài liệu Bevacizumab and cetuximab for the treatment of metastatic colorectal cancer docx

... from data in the RCT. The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT. The data from the monotherapy arm ... this situation, where no other active treatment was available, could prolong survival for a number of months if the disease responded to the drug. The Committee was therefore persuaded that cetuximab ... appraisal guidance 118 20 of the drugs were tolerated willingly because of the perceived benefit, whereas for others the side-effect profile may be more of a consideration. The Committee heard from...

Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique

... investigated the efficacy of facet debridement for the treatment of facet joint pain. Summary of background data: Facet joint disease, often due to degenerative arthritis, is common cause of chronic ... considering the endoscopic option. The facet injections in these 72 patients gave 50 to 100% relief of their pain in 86% of the patients with a median relief period of 3 months. The range of relief ... the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue. Limitations of the...

Báo cáo y học: "Endoscopic thoracic laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 case"

... laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 cases Scott M.W. Haufe 1,2 , Ryan A. Baker 3 and Morgan L. Pyne 3 1. Chief of Pain Medicine and Anesthesiology ... quality of life. Conservative therapy is the initial treatment of choice, but fails to provide relief in a substantial number of patients. Central and foraminal stenosis with entrapment of descending ... to evaluate the efficacy of endoscopic laminoforamino-plasty (ELFP) in the treatment of thoracic radiculopathy. Methods: Twelve patients with radicular pain involving the lower thoracic levels...

Behavior of Nitrite Oxidizers in the Nitrification/Denitrification Process for the Treatment of Simulated Coke-Oven Wastewater

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored. Then, each of the samples were divided into two. One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers. Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved. The results ... Yet, there are cases where biological nitrification has been applied successfully. The authors examined the applicability of the nitrification/denitrification process for the treatment of coak-oven...

Contact-Adsorption-Regeneration-Stabilization Process for the Treatment of Municipal Wastewater

... with the increased HRT of the adsorption tank. From an engineering application point of view, the appropriate operational parameters of the recycle ratio, HRT of the regeneration tank, HRT of the ... technical feasibility of this process was demonstrated. The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated. The removal efficiency ... reports the experimental results of the CARS process for the municipal wastewater treatment. The technical feasibility of this process was demonstrated, and the process optimization was performed....

Tài liệu Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom pdf

... minimising the impact of disease. At least 30% of patients require surgery in the first 10 years of disease andapproximately 70–80% will have surgery in their lifetime.3.3 Other disease sites≥ ... Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom23Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United ... prednisolone for the treatment of activepaediatric Crohn’s disease. J Pediatr Gastroenterol Nutr 2003; 36:248-52.[38] Escher JC. Budesonide versus prednisolone for the treatment of active Crohn’s disease...

Management of Sickle Cell Disease in Children doc

... 15-20% of infants and young children with sickle cell anemia die before the age of 5, usually of septicemia or meningitis. In children under 6 years of age with sickle cell disease, the predominant ... Management of Sickle Cell Disease in Children. Page 3 of 15 Inclusion Criteria: • Sickle cell patients presenting with signs of VOC. • Presenting sign relative to the site of the VOC and ... study of outpatient treatment with ceftriaxone for selected febrile children with sickle cell disease. N Engl J Med 1993; 329 (7): 472-476 [a randomized study of children with sickle cell disease...

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