... Varvas1, Alan R. Brash2 and Nigulas Samel11Department of Chemistry, Tallinn University of Technology, Estonia;2Department of Pharmacology, Vanderbilt UniversitySchool of Medicine, Nashville, ... conversion of arachidonic acid to prostaglandin (PG) endoperoxide, theprecursor of PGs and thromboxanes [1–5]. PG hormonesact as important mediators i n t issue homeostasis and a lso ininflammation and ... 2 and 3, and Table 2 ). Equivalentamounts of wild-type and mutant proteins as quantified byWestern analysis gave similar conversion of the radio-labelled substrate. The Val349Ile mutant of...