Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc

... that expression of the Dnmt1 gene is controled by Sp1 and Sp3 and that p300 is involved in the activation by Sp3. Keywords: Dnmt1 gene; activation of transcription; Sp1; Sp3; p300. Transcription ... to generate the mutants. Ó FEBS 2002 Transcription of gene for DNA methyltransferase 1 (Eur. J. Biochem. 269) 2963 Regulation of transcription of...

Ngày tải lên: 22/02/2014, 07:20

... approach of image analysis, which is established by us recently [4,11], was used to analyze the unfolding dynamics and also was introduced into the analysis of the thermal transition study by CD and 1 HNMR. MATERIALS ... entropy values reflect the ÔentropyÕ of the spectra, which is the sum probability of the peak intensity in a certain region. In other words, the...

Ngày tải lên: 21/02/2014, 01:21

... residue and/ or by the binding contribution from theGalNAcresidue. Docking the glycopeptide to the antibody the sugar ring has little contact to the protein surface. Only the N-acetyl methyl group is ... complex of a 13mer peptide TSAPDTRPAPGST and the an tibody SM3 was deter- mined by Dokurno et al. [19]. They report a significant contribution of Arg4 to b inding by...

Ngày tải lên: 21/02/2014, 15:20

... concentration and to the residual amounts of water. The carbonyl region of the spectrum is mostly unaffected by the HPBC difference bands (Fig. 5B); the uncorrected data yielded the same difference band ... Universita ¨ tGo ¨ ttingen, Germany), DIAMOND for the graphic display of structures (K. Brandenburg, Univer- sita ¨ t Freiburg, Germany). Determination of quantu...

Ngày tải lên: 21/02/2014, 15:20

... coordination of the phosphorylation of UTP and hydrolysis of glutamine for optimal efficiency in CTP synthesis rather than just acting to increase the rate of glutamine hydrolysis itself. Keywords: CTP synthase; ... rearrangements of the monomer that brings together the glutaminase site and the active site. (C) GTP locks the enzyme in the active form for CTP synthesi...

Ngày tải lên: 21/02/2014, 15:20

... phos- phorylation. Phosphorylated and thereby activated type I receptor phosphorylates Smads, which then form oligomeric complexes and enter the nucleus to either induce or suppress gene expression by ... extracellular matrix synthesis and degradation, and the control of epi- thelial ⁄ mesenchymal interactions during embryogene- sis. Other functions include wound healing an...

Ngày tải lên: 19/02/2014, 02:20

... transduction by members of the TNF receptor and IL1/Toll-receptor family [1,2]. The TRAF proteins are characterized by a C-terminal homology domain of about 200 amino acids, called the TRAF domain. The ... To determine the cellular localization of the GFP or YFP fusion proteins, HeLa cells were transiently transfected with the respective expression plasmids and...

Ngày tải lên: 21/02/2014, 15:20

... extent of stimulation of the membrane and soluble yeast PtdEtn- PLD activity by Ca 2+ and their inhibition by other divalent cations is highly comparable. The mechanism of action of Ca 2+ ions in ... phosphate synthase [32]. It is therefore highly likely that yeast PtdEtn-PLD is encoded by a non-HKD gene and may thus represent a novel PLD gene family. A prokaryotic...

Ngày tải lên: 22/02/2014, 07:20

... anandamide and 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By ... macrophages and lymphocytes as far as the amounts of the endogenous ligands are concerned, but differently in terms of the levels of the two cannabinoid rec...

Ngày tải lên: 22/02/2014, 07:20

... MAPK ERK1 15 37 55 P P P p53 Fig. 1. Regulation of DNA fragmentation by phosphorylation of the MAPK family and mitochondrial proteins. Phosphorylated ERK prevents the activation of caspases and the Bcl-2 family, whereas these ... in regulating the activity of an isoform of PP1, PP1a [3]. Similarly, activation of caspase-8 and -3 is regulated through their phosph...

Ngày tải lên: 14/02/2014, 22:20