... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, rat chymotrypsin B, is highlighted by bold type. The loops are boxed and ... 2).Finally it is of interest regarding the in vivo mechanism of inactivation, that chymotrypsin and trypsin, mixed in concentration ratios close to those in the intestines, did notexpedite the inactivation ... in the interdomain and autolysis loops in the inactivation of chymotrypsin. At first, D-chymo-trypsin and the interdomain and autolysis loop mutants weresubjected to digestion with trypsin. For...