Tài liệu Báo cáo khoa học: "Probing the lexicon in evaluating commercial MT systems Martin" pot
... Probing the lexicon in evaluating commercial MT systems Martin Volk University of Zurich Department of Computer Science, Computational Linguistics Group Winterthurerstr. 190, ... technical, linguistic and ergonomic issues. As part of the linguistic evaluation we wanted to determine the lexical coverage of the MT systems since only some of the systems provide...
Ngày tải lên: 22/02/2014, 03:20
... substrate was determined on the basis of the possible binding sites identified by the Site Finder function in moe, as well as the relative position of the indole substrate in the crystal structure of ... lies at the entrance of the substrate- binding pocket of the enzyme, leading to the substrate channel. Mutation from isoleucine to leucine results in a larger entranc...
Ngày tải lên: 19/02/2014, 02:20
... permuta- tions originating from the same source doc- ument, as opposed to the original pairwise rankings. We also study the effect of the permutations used in training, and the effect of the coreference ... 133–142. Thorsten Joachims. 2006. Training linear SVMs in linear time. In Proceedings of the 12th ACM SIGKDD International Conference on Knowledge Discovery and Data Mini...
Ngày tải lên: 22/02/2014, 02:20
Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... contribute to providing chromophore to melanopsin to maintain their light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to be investigated. Earlier ... RPE65c in the inner retina, including Mu ¨ ller cells, but not in the RPE. Furthermore, double-immuno- staining of dissociated retinal cells using antibodies for RPE65c and gluta...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... residues directly involved in ligand binding, presumably abolishing the interaction with signaling partners. The remaining mutations alter amino acids located outside the ligand-binding pocket and ... locations of the missense mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase domain. The mutated residues ar...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: Seeking the determinants of the elusive functions of Sco proteins pptx
... close to the N-terminal trans- membrane helix anchoring the protein to the inner membrane of mitochondria [27]. Therefore, the N-ter- minal segment (containing the residues protruding into the mitochondrial ... [85]. The histidine ligand coordination is therefore the discriminating factor for introducing a high-affinity copper-binding site in Sco proteins. Such a general mode...
Ngày tải lên: 14/02/2014, 18:20
Tài liệu Báo cáo khoa học: Resolving the native conformation ofEscherichia coli OmpA docx
... cOHB-modification of the C-terminal domain in the periplasm would increase the hydropho- bicity of hydrophilic segments in this domain, and thereby enable them to be incorporated into the bilayer. In support ... two-domain structure of OmpA, in which the N-terminal domain (residues 1–170) crosses the membrane eight times in antiparallel b-strands, and the 155-residue C-...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Understanding the binding properties of an unusual metal-binding protein ) a study of bacterial frataxin pdf
... enhance the paramagnetic effects around the binding site: they induce a line broadening of 1–100 Hz in nuclei located within 5 A ˚ of the binding site, depending on the molecular mass of the protein ... Although it remains unclear which of these hypotheses reflects most closely the cellular role of frataxin, their common denominator is a link between frataxin and iron. Interestin...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf
... 2007) doi:10.1111/j.1742-4658.2007.06051.x The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers ... effects via the prosurvival serine-threonine protein kinase, Akt (also known as protein kinase B) [2]. In agreement with this, elevated levels of activated Akt in...
Ngày tải lên: 18/02/2014, 16:20