Tài liệu Báo cáo khoa học: "TRANSPORTABLE NATURAL-LANGUAGE INTERFACES: PROBLEMS AND TECHNIQUES" pot

Tài liệu Báo cáo khoa học: "Panel on Natural Language and Databases" pot

... query while we wait for miracles of technology to fill our demands for ever greater processing speed. A second reason for not yet abandoning the database query as a test environment is that a ... evaluat- ing and comparing such systems. [t seems clear that even the task of answering database queries will provide a more than adequate supply of linguistically interesting problems for ... theoretically interesting problems to solve in constructing a natural lan- guage interface for databases. For example, in building such an interface, we have recently designed and implemented a hierarchically...

Tài liệu Báo cáo khoa học: "TRANSPORTABLE NATURAL-LANGUAGE INTERFACES: PROBLEMS AND TECHNIQUES" pot

... TRANSPORTABLE NATURAL-LANGUAGE INTERFACES: PROBLEMS AND TECHNIQUES Barbara J. Grosz Artificial Intelligence Center SRI International, Menlo Park, CA 94025 Department of Computer and Information ... as simplifying the general problem and where, on the other hand, transportability (and the way in which database systems typically structure information and view the world) makes things ... can be defined in terms of a count operator and the domain entities that are to be counted), and they present similar problems for transportability and database access (see section 5). The...

Tài liệu Báo cáo khoa học: How to remain nonfolded and pliable: the linkers in modular a-amylases as a case study ppt

... extended and pliable. Unfolding is mediated through adepletion of hydrophobic residues and an enrichment of hydrophilic resi-dues, amongst which Ser and Thr are over-represented. An extended and ﬂexible ... rigid and hydrophilic peptide. The abundance of Ser and Thr residues in linkers from animals also providesnumerous potential targets for O-linked glycosylation.By contrast, only ﬁve potential ... linker peptides and the engi-neering of size and composition variations in order toaddress their function in activity, substrate binding and structural dynamics.Materials and methodsExperimental...

Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

... experimentalcondition were built and then compared; spots were quanti-ﬁed on the basis of their relative volume (spot volume nor-malized to the sum of the volumes of all the representativespots) and those that ... Japan) and analyzed withimagemaster 2d platinum software, version 5.0 (GEHealthcare). Spots were detected automatically by the soft-ware and manually reﬁned; gels were then matched and theresulting ... 4909overexpression, parkin and PTEN-induced putativekinase 1 loss-of-function and UCHL1 mutation, leadto an impairment of neuronal dopamine homeostasisby interfering with the vesicular storage and releasemechanisms....

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

... progression and tumour angio-genesis. Nat Rev Cancer 8, 632–645.47 Klagsbrun M & Eichmann A (2005) A role for axonguidance receptors and ligands in blood vessel develop-ment and tumor angiogenesis. ... (e.g.hypoxia-inducible factor and Src-suppressed C kinase substrate ⁄ AKAP12) and soluble factors (e.g. vascular endothelial growth factor and angiopoie-tin-1), as well as axon guidance molecules and neurotrophic ... trans-ferrin and leptin, to cross the BBB [13].Molecular basis of brain angiogenesis and barriergenesisHypoxia and the hypoxia-inducible factor systemAs an embryo develops and its structure...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... cells and astrocytes, and the tight junctions of vascular endothelial cells (ECs)in the BBB are well organized with claudins and ZO-proteins through a decrease in angiogenesis signaling and an ... in both embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep-tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1),Fig. 1. The VEGF–VEGFR system and theinhibitors of ... FiveVEGF family members and three VEGFRsare encoded in the human genome. In addi-tion, VEGF-E encoded in the Orf virus binds and activates only VEGFR-2. Anti-(VEGF-A)IgG and aptamer, as well...

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

... worth not-ing that Lyden and colleagues have proposed a ‘clean-up hypothesis’, whereby newborn vessels serve to facil-itate macrophage inﬁltration, and clear up and removecellular debris ... angiogenesis and neurogenesis responsesin the delayed stroke phase. VEGF can trigger remod-eling responses in both endothelial cells and neurons(see Fagan et al. [57] and Hansen et al. [58] for full and ... forlater angiogenesis and brain recovery (Fig. 3). Becausesimilar signals and substrates are involved, one willhave to be very careful in terms of understanding how and when these injury-into-repair...

Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc

... ofVrp1p and Las17p in yeast and WIP and WASP-fam-ily proteins in mammalian cells are direct and resultin constitutive and apparently stable complexes[28,29,31,32]. In yeast, Vrp1p and Las17p ... functionsof Vrp1p in endocytosis, cytokinesis, and growth atelevated temperature, on the one hand, and in corticalactin-patch polarization, on the other hand, are at leastpartially distinct [23]. ... interaction with actin and that GST-C-Vrp1p465)533binds endogenous actin in yeast lysates and directly binds puriﬁed yeast and rabbit skeletalmuscle G-actin in vitro (Fig. 4B–D and data notshown)....

Tài liệu Báo cáo khoa học: Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis doc

... with TRAIL and PIs. TRAIL-sensitive cells (U87 and U251) and TRAIL-resistant cells (U343,U373, MZ-54, and MZ-18) were treated with250 ngÆmL)1TRAIL and the PIs MG132(2.5 lM) and epoxomicin ... R1 and death receptor 5(DR5) ⁄ TRAIL R2, and this then leads to recruitmentof the adaptor protein Fas-associated death domain and the initiator caspases procaspase-8 and procaspase-10, and ... inhibitors MG132 and epoxomicinwere capable of potentiating TRAIL-induced apoptosis in TRAIL-sensitiveU87 and U251 cells and of reactivating apoptosis in TRAIL-resistant U343 and U373 cells....

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... PTP1B, and RPTPa) also undergoes a large conformationalchange in many, but not all, PTPs [9,10]. In the absenceof ligand, the WPD loop of PTP1B and RPTPa adoptsan open (inactive) conformation, and ... oxidation [24].Phosphatase and tensin homolog (PTEN) is readily oxi-dized and has an active site that is narrower than, and half as deep as (5 · 11 A˚opening, and 8 A˚depth), thePhyAsr ... collection and reﬁnement ofPhyAsrI200 and PhyAsroxare shown in Table 2. Statisticsfor the data collection and reﬁnement of the structure ofPhyAsr at ionic strengths of 300 mm, 400 mm and 500...

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