Tài liệu Báo cáo khoa học: "TRANSPORTABLE NATURAL-LANGUAGE INTERFACES: PROBLEMS AND TECHNIQUES" pot

... query while we wait for miracles of technology to fill our demands for ever greater processing speed. A second reason for not yet abandoning the database query as a test environment is that a ... evaluat- ing and comparing such systems. [t seems clear that even the task of answering database queries will provide a more than adequate supply of linguistically interesting problems for...

Ngày tải lên: 21/02/2014, 20:20

... TRANSPORTABLE NATURAL-LANGUAGE INTERFACES: PROBLEMS AND TECHNIQUES Barbara J. Grosz Artificial Intelligence Center SRI International, Menlo Park, CA 94025 Department of Computer and Information ... as simplifying the general problem and where, on the other hand, transportability (and the way in which database systems typically structure information and view the worl...

Ngày tải lên: 21/02/2014, 20:20

... extended and pliable. Unfolding is mediated through a depletion of hydrophobic residues and an enrichment of hydrophilic resi- dues, amongst which Ser and Thr are over-represented. An extended and flexible ... rigid and hydrophilic peptide. The abundance of Ser and Thr residues in linkers from animals also provides numerous potential targets for O-linked glycosylation. By contrast,...

Ngày tải lên: 14/02/2014, 18:20

... experimental condition were built and then compared; spots were quanti- fied on the basis of their relative volume (spot volume nor- malized to the sum of the volumes of all the representative spots) and those that ... Japan) and analyzed with imagemaster 2d platinum software, version 5.0 (GE Healthcare). Spots were detected automatically by the soft- ware and manually refined; gels wer...

Ngày tải lên: 15/02/2014, 01:20

... progression and tumour angio- genesis. Nat Rev Cancer 8, 632–645. 47 Klagsbrun M & Eichmann A (2005) A role for axon guidance receptors and ligands in blood vessel develop- ment and tumor angiogenesis. ... (e.g. hypoxia-inducible factor and Src-suppressed C kinase substrate ⁄ AKAP12) and soluble factors (e.g. vascular endothelial growth factor and angiopoie- tin-1), as well as...

Ngày tải lên: 18/02/2014, 11:20

... cells and astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO- proteins through a decrease in angiogenesis signaling and an ... in both embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep- tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1), Fig. 1. The VEGF–VEGFR system and the...

Ngày tải lên: 18/02/2014, 11:20

... worth not- ing that Lyden and colleagues have proposed a ‘clean- up hypothesis’, whereby newborn vessels serve to facil- itate macrophage infiltration, and clear up and remove cellular debris ... angiogenesis and neurogenesis responses in the delayed stroke phase. VEGF can trigger remod- eling responses in both endothelial cells and neurons (see Fagan et al. [57] and Hansen et al....

Ngày tải lên: 18/02/2014, 11:20

... of Vrp1p and Las17p in yeast and WIP and WASP-fam- ily proteins in mammalian cells are direct and result in constitutive and apparently stable complexes [28,29,31,32]. In yeast, Vrp1p and Las17p ... functions of Vrp1p in endocytosis, cytokinesis, and growth at elevated temperature, on the one hand, and in cortical actin-patch polarization, on the other hand, are at least parti...

Ngày tải lên: 18/02/2014, 16:20

... with TRAIL and PIs. TRAIL-sensitive cells (U87 and U251) and TRAIL-resistant cells (U343, U373, MZ-54, and MZ-18) were treated with 250 ngÆmL )1 TRAIL and the PIs MG132 (2.5 l M) and epoxomicin ... R1 and death receptor 5 (DR5) ⁄ TRAIL R2, and this then leads to recruitment of the adaptor protein Fas-associated death domain and the initiator caspases procaspase-8 and proca...

Ngày tải lên: 18/02/2014, 17:20

... PTP1B, and RPTPa) also undergoes a large conformational change in many, but not all, PTPs [9,10]. In the absence of ligand, the WPD loop of PTP1B and RPTPa adopts an open (inactive) conformation, and ... oxidation [24]. Phosphatase and tensin homolog (PTEN) is readily oxi- dized and has an active site that is narrower than, and half as deep as (5 · 11 A ˚ opening, and 8 A ˚ dept...

Ngày tải lên: 18/02/2014, 18:20