Tài liệu Báo cáo Y học: Antibacterial and antifungal properties of a-helical, cationic peptides in the venom of scorpions from southern Africa pptx

... program (http://www.expasy.ch/cgi-bin/peptide-mass.pl). Chemical synthesis of parabutoporin and opistoporin The peptides were prepared by solid-phase synthesis by Ansynth Service B.V. (the Netherlands) using the ... same family, independent of the continent and region where they live. In this study, the biological activity of parabutoporin and opistoporin 1 is compare...

Ngày tải lên: 21/02/2014, 15:20

... [6,7]. The methylation pattern is created by de novo methylation and demethyla- tion of the DNA, and maintained during mitosis by maintenance methylation [reviews 8,9]. De novo methyla- tion of DNA ... methyl groups are always introduced, one slowly by Dnmt3a or by de novo methylation catalyzed by Dnmt1 and the second one very fast. Therefore, this effect can only double the...

Ngày tải lên: 21/02/2014, 01:21

... Also other amino- glycosides, as kanamycin A, neomycin B and a synthetic neomycin-neomycin dimer have been shown to induce fragmentation of tRNA Phe at Y3 7 and additionally at m 7 G46 in the variable ... results of the strand-break assay of yeast tRNA Phe in the presence of Ami, Cu(II)-Ami and the Cu(II)-Ami-H 2 O 2 system, performed by means of poly- acrylamide...

Ngày tải lên: 21/02/2014, 01:21

... for the conformational stability of the protein and its proper interaction with the membrane protein-sorting machinery. The importance of helix 1 in stabilizing the UGT protein may also be inferred from ... [24]. Heparin-like glycosaminoglycans that contain galactose and N-acetylgalactosamine residues are involved in the wingless signaling [25]. The DmUGT protein w...

Ngày tải lên: 21/02/2014, 15:20

... residue resulting from the cloning procedure has apparently been cleaved off during the maturation of the e nzyme. Enzyme activity studies The lysozyme activities of the various hevamine variants ... between the se two classes. Role of Tyr183 in catalysis In previous crystallographic studies it was shown that the hydroxyl side chain of Tyr183 is within hydrogen bon...

Ngày tải lên: 22/02/2014, 04:20

... (G66, R68 and G74) of Calb I–II lack the side-chain oxygens expected to provide calcium-binding ligands. The absence of calcium-binding to the EF-hand II motif of Calb has been shown in the individual ... C.P. (1999) A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inh...

Ngày tải lên: 22/02/2014, 07:20

... results indicate that SPO14/PLD1 may be involved in regulating the expression of genes that are part of the INO1 regulon [13]. Therefore, we examined the effect of the presence of inositol and choline ... our results indicate that yeast PtdEtn-PLD activity is highly regulated: the enzyme is acutely activated upon entry into the cell cycle and following inactivation...

Ngày tải lên: 22/02/2014, 07:20

... presence of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the ... min), two fractions were obtained: a top leukocyte band containing mononu- clear cells (monocytes and lymphocytes) and a lower band containing polymorphonuclear leukocyte...

Ngày tải lên: 22/02/2014, 07:20

... carboxyl oxygen atoms of D8, D9, by the carboxamide oxygen of N92, by the hydroxyl oxygen of S39 and by the oxygen atoms of two water molecules, and has an approximate octahedral geometry (Fig. ... tight association. The area buried in the interface of the subunits related by twofold along a in F222-SurE is comparable (7000 A ˚ 2 ). In contrast, the AD and...

Ngày tải lên: 18/02/2014, 14:20

... their binding to and activa- tion of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6–Axl system is the unique ability of Gas6 and pro- tein S to tether their ... as the Gas6–Axl system, Gas6 being the lig- and. Since the discovery of Axl in 1991, a tantalizing assortment of roles for the Gas6–Axl system has been revealed, in...

Ngày tải lên: 19/02/2014, 05:20