Tài liệu Báo cáo khoa học: Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity docx

... 270) 3903 Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity Merlijn Bazuine, D. Margriet Ouwens, Daan S. Gomes de Mesquita and J. ... glucose uptake as well as MAPKAP-K2 and p38- phosphorylation (Fig. 6A,B). In insulin-signalling, p38 MAPK has been implied in enhancing the intrinsic...

Ngày tải lên: 21/02/2014, 00:20

... betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also known as heregulin) that binds to ERBB3 and ERBB4. NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 ... domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lob...

Ngày tải lên: 16/02/2014, 09:20

... SO (1993) ADP- and thapsigargin-evoked Ca 2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded ... examined using two structurally distinct inhibitors, wortmannin and LY294002 [21]. In the presence of ADP ⁄ P2Y 12 activity, wortmannin or LY294002 suppressed the thrombin-induced C...

Ngày tải lên: 18/02/2014, 16:20

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... observed both in vitro and in vivo, and these delayed secretions were crucial to the increased mortal- ity in septic patients and experimental animals [35]. The find...

Ngày tải lên: 14/02/2014, 18:20

... of opening of the initial double strand and the annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invading strand, according to ... unwinding. High-resolution X-ray struc- tures have given insights into the mechanism(s) of DEAD-box helicases. The binding sites for double- stranded RNA and ATP overlap, resulting in coupl...

Ngày tải lên: 14/02/2014, 19:20

... To distinguish total binding from non-specific binding, cells were incubated for 10 min in either PBSCM alone or PBSCM containing 200 lm cocaine for inhibition of DAT or 200 lm S-citalopram for inhibition ... a-synuclein; DA, dopamine; DAT, dopamine transporter; NET, norepinephrine transporter; PBSCM, phosphate-buffered saline supplemented with Ca and Mg; PD, Parkinson’s disease; SERT, ser...

Ngày tải lên: 14/02/2014, 21:20

... binding and PI staining were performed according to [44]. Following incubation with 1.0 lgÆmL )1 annexin V and 4.0 lgÆmL )1 PI for 20 min, cells were analyzed by flow cytometry. Preparation and ... variety of cell types, including hepatocytes, to long-chain saturated fatty acids (SFAs) led to increased expression of proin- flammatory cytokines, inhibition of insulin signaling, induction o...

Ngày tải lên: 14/02/2014, 22:20

... described in the text. After removal of unbound cobalamin at 0 min (thick solid line), 30 min (thin solid line), 60 min (thin long-dashed line), 120 min (thin short-dashed line), 240 min (thin dotted ... free adeninylpentylcobalamin (AdePeCbl) (an inactive coenzyme analog containing the adenine ring in the upper axial ligand; a model of intact coen- zyme, AdoCbl) in the presence of ATP...

Ngày tải lên: 15/02/2014, 01:20

... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig. 1). Early clinical studies showed ... The binding of ligand to EGFR induces receptor dimerization and consequent confor- mational changes that result in activation of the intrin- sic tyrosine kinase, receptor autophosphoryla...

Ngày tải lên: 16/02/2014, 09:20

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions. FYRC and FYRN domains are involved in heterodimerization between MLL N and MLL C terminal fragments. High-mobility group (HMG) dom...

Ngày tải lên: 16/02/2014, 14:20