Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf

... 3497 Role of cleavage and shedding in human thyrotropin receptor function and trafficking Myle ` ne Quellari 1 , Agne ` s Desroches 1 , Isabelle Beau 1 , Emmanuelle Beaudeux 1 and Micheline Misrahi 1,2 1 INSERM ... cleavage and shedding on the one hand, and the receptor activated by the ligand on the other hand. Cleavage and shedding of a receptor...

Ngày tải lên: 21/02/2014, 00:20

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... con- centrations of tumor necrosis factor-a and interleukin-6, and increased hepatic mRNA levels of tumor necrosis factor-a and interleukin-6 were decreased by depletio...

Ngày tải lên: 14/02/2014, 18:20

... have indi- cated that the CagA PY -induced cell elongation pheno- type also involves tyrosine dephosphorylation of cortactin, vinculin and ezrin, which are three well- known actin-binding proteins ... the amount of intracellu- lar CagA PY . Cortactin, ezrin and vinculin are all Src substrates, and Src inactivation causes dephosphoryla- tion of these proteins and is crucial for t...

Ngày tải lên: 14/02/2014, 19:20

... Westrick RJ & Ginsburg D (1998) Comparative mapping of distal murine chro- mosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. ... acting as a ligand-inducible transcription factor and has been implicated in the control of keratinocyte survival. In the mouse keratinocyte cell line SP1, serum starvation induced...

Ngày tải lên: 18/02/2014, 18:20

... prepared from CT and CT-B-injected rats (Fig. 3A). An increase in ARF content was observed in endosomal fractions isolated 5 min postinjection of CT-B, and this increase was maintained for up to 60 min (Fig. ... cathepsin D inhibitor pepstatin A partially inhibited, both in vivo and in vitro, the cAMP response to cholera toxin. This cathepsin D-dependent action of cholera to...

Ngày tải lên: 19/02/2014, 02:20

... and cell survival. They bind and activate a specific tyrosine kinase receptor that is coupled to multiple intracellular signaling pathways [17,18]. Activation of tyrosine kinase receptors is involved ... transcription, were increased in response to EGF. Pretreatment of the cells with PD98059, an inhibitor of MAP kinase kinase, inhibited the EGF-induced c-Fos and c-Jun expressio...

Ngày tải lên: 19/02/2014, 06:20

... charged amino acid side chains, R397 and R120, are also involved in fosfomycin binding, and in view of the multitude of interactions, it was assumed that deletion of a single interaction would not ... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins. However, two other posi...

Ngày tải lên: 19/02/2014, 13:20

... on conformation of inhibitor main chain. Thus, different inhibitors differ not only in t he binding affinity, bu t a lso in the degree o f freedom of the inhibitor inside the binding tunnel. Some s pecial inhibitors ... that t he strain imposed on inhibitor during docking into the binding site of pr otease does not allow correct orientation of the hydroxyl group to catalytic aspart...

Ngày tải lên: 19/02/2014, 16:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... would enhance or diminish the impact of HSF2 deficiency. Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryos The role of HSF2 in oogenesis...

Ngày tải lên: 18/02/2014, 04:20

... side-chains of K89, residue 90 and residue 97 are shown. The dis- tances between the e-amino groups of K89 and K90, and between the e-amino group of K90 and the guanidino group of R97, in the ... because of the intrinsic flexibility of the loop containing His124 and the crystal packing effect. Destabilization mechanism of So-RNase HI A combination of the six thermos...

Ngày tải lên: 18/02/2014, 13:20