Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

... of pathogen-free human recombinant IF. Human IF was successfully expressed in the recombinant plant Arabidopsis thaliana. Extract from fresh plants possessed high B 12 -binding capacity corresponding to ... Aarhus, Denmark Intrinsic factor (IF) is the gastric protein that promotes the intestinal uptake of vitamin B 12 . Gastric IF from animal sources is used in diagno...

Ngày tải lên: 21/02/2014, 00:20

... occur- ring in many different combinations are the P-loop nucleotide triphosphate hydrolase domain, the epider- mal growth factor (EGF) domain, the SH3 domain, the P-kinase domain and the domains involved ... definned as the length of the amino acid sequence preceding the next domain in the arrangements, expressed as the percentage of the calcu- lated average leng...

Ngày tải lên: 19/02/2014, 07:20

... divided in two phases according to the intensity and the duration of the stress. An initial adaptive response culminates in the temporary inhibition of protein synthesis, providing cells with the ... synthesis was initially hindered following stearate administration and was completely interrupted at longer incubation periods. Interestingly, the interruption of TAG synthe- sis...

Ngày tải lên: 14/02/2014, 22:20

... All ERBB proteins have four functional domains: an extracellular ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2]. The extracellular domain ... extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lobe, and ATP binds to the cleft formed between...

Ngày tải lên: 16/02/2014, 09:20

... and small- molecule tyrosine kinase inhibitors, such as gefitinib and erlotinib, which target the intracellular tyrosine kinase domain of the EGFR. Furthermore, recent clinical and laboratory studies ... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig. 1). Early clinical st...

Ngày tải lên: 16/02/2014, 09:20

... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... substrates. The lack of inhibition observed with benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine (Fig. 5B) suggests differences in binding of the...

Ngày tải lên: 19/02/2014, 07:20

... of PDZ binding on the interactions of the Grb4-SH2 domain with the ephrinB2(301–333)-pY304 peptide. (A) The PDZ- binding curves are for the fluorescein-labeled peptides including eph- rinB2(301–333) ... one another (Table 1). These observations demonstrate that the flexibly linked SH2-binding and PDZ-binding sequences in the ephrin B peptide (Fig. 9) can accept the simultaneou...

Ngày tải lên: 19/02/2014, 12:20

... which are of either of the types appearing in the Orig. Edge column. As the table shows, the modified structures cover a significant portion of the tokens. Indeed, 42.9% of the tokens in the corpus ... Decoding is done using the Viterbi algorithm 4 . For each of these algo- rithms we present the performance gain when com- pared to the original parameters. The training...

Ngày tải lên: 20/02/2014, 04:20

... and mine it very deeply, not necessarily discovering every aspect of the domain but requiring that the various aspects be integrated with one another to produce a coherent whole. Even in the ... officers represented in it. The system merely made no distinction between "all" and "any", and interpreted the final query to mean the But, you are probably...

Ngày tải lên: 21/02/2014, 20:20

... solutions. The ligand bound was interpreted as GMP because the N2 of the base makes a hydrogen bond to a main chain car- bonyl. Binding of a xanthine base from XMP in the same position, would lead to the ... producing the largest increase in calculated DT agg (i.e. the difference in midpoint of the aggrega- tion process measured by DSLS) were PRPP, GMP and IMP. Large inc...

Ngày tải lên: 15/02/2014, 01:20