Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... mecha-nism of transphosphorylation, which implies the ABFig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-siteresidues of the 20 conformers of the solu-tion structure ... second-ary structure elements. As in other ribotoxins, theseABCFig. 2. Representation of the 3D structure of HtA in solution. (A) Superposition of the 20 best structures obtained in this work(PDB ... electrostatically with the othercharged groups. In the NMR structures, this sidechain of D40 is a short distance (£ 3A˚) from the sidechains of H42 and R95. Finally, the aromatic ring of F126, placed...
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Tài liệu Báo cáo khoa học: Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom docx
... effect.Description of the toxin structure and potential surface The characteristic NOE connectivities, reported in Fig. 3A,and the analysis of the / and w angle distribution allowed the identification of the ... )1topology [47] of the triple-stranded antiparallel b-sheet wasFig. 3. Summary of data used in the determination of the secondary structure of crotamine. (A) Primary sequence of Crt with the sequential ... to the mean structure, of 0.91 ± 0.15 A˚for backbone atomsand 1.47 ± 0.15 A˚for all heavy atoms. Further details of the statistics of the NMR models are listed in Table 1.Analysis of the...
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
... and contacting the DNA backbone. The solution structure of the MBD of MBD1 shows high similarity to that of MeCP2 except for the C-terminus [18]. At the C-terminus of the MBD, MeCP2 exhibits ... (c )MeCP2] [15]. The solution structure of the MBD of rat (r )MeCP2 hasrecently been determined [17]. The MBD adopts a wedge-shaped structure, composed of an antiparallel b-sheet onone face of ... negative charges on the surface of the domain Fig. 4. Comparison of cMeCP2 MAR-BD with rMeCP2 MBD and MBD1 MBD. Ribbon plots of rMeCP2 MBD [17] (left), the core region of cMeCP2 MAR-BD (residues...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
... accumulation of the toxin by the food chain in the organisms living close to the zoan-thid colonies [3].It has been reported that dinoflagellates of the genusOstreopsis are the most probable origin of ... palytoxin action against the actincytoskeleton (Fig. 3). At present, in spite of the impor-tance of the unpolymerized actin pool for the mainte-nance of the F-actin system, the cellular responseFig. ... with the cytosolic Ca2+changes; there-fore, this ion represents an important factor in altering this structure, but itis not the only cause. The goal of the present minireview is to compile the findings...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx
... consumption of the algae by the shellfish, PTX-2can be metabolized to other PTX derivatives. In the digestive gland of the scallop P. yessoensis, the C43methyl group in PTX-2 is oxidized to the alcohol(PTX-1), ... supports the idea that lactone ring integrity is essential for the action of PTXs; oxidation on C43 decrease the toxic-ity of the molecule, and oxidation on C34 does notaffect the potency of PTXs.Unusual ... nucle-ation. On the basis of models of the actin filament,PTX binding would disrupt key lateral contactsbetween the PTX-bound actin monomer and the lowerlateral actin monomer within the filament, thereby...
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Tài liệu Báo cáo khoa học: "Automatically Extracting Polarity-Bearing Topics for Cross-Domain Sentiment Classification" pptx
... in the Electronics domain. Likewise, in the Book+Kitch.set, “stainless” rarely appears in the Book domain and “interest” does not occur often in the Kitchen domain and they are grouped under the ... to the in -domain gold standard. The last row shows the average loss overall the four domains.Parameter SensitivityThere is only one parameters to be set in the JST-IG approach, the number of ... knowledge, the results achieved using JSTfeature augmentation are the state -of- the- art for both the MR and the MDS datasets.6.3 Domain AdaptationWe conducted domain adaptation experiments onthe...
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Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc
... along the horizontal axis wasused to convert the left structure to the right structure. The N-ter-minus is at the left for every structure. The best-fit overlays of the 10 lowest overall energy structures ... [1]. The 18.5 kDaisoform of myelin basic protein (MBP) is one of the most abundant proteins in CNS myelin; MBP maintains the compaction of the sheath by anchoring the cytoplas-mic faces of the ... Oi Ni+4< 3.5) did not improve the quality of the 10 best structures, but reduced the occurrence of NOE-violated structures over the ensemble of 100structures. Approximately 200 NOE distance...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... (B) structure alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII.Fig. 6. Structure of a representative folded conformer of AII ... quantitativecomparison of the structure of AII in solution with the X-ray structure of AII complexed to the Fab131 mAb. In Fig. 7A, asequence alignment is represented of the backbone of the conformational ... obtained after the sequence and structure alignment of the two structures by using the program Profit1.8. Remarkably, the superposition of the solution state and the bound structure of AII exhibits...
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Tài liệu Báo cáo khoa học: Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc
... bondbetween the hydrogen of OH9 (HO9) and the oxygen of OH7 (OH7) which can contribute to the stabilization of the C7–C9 region of the macrolide.Structural analysis of nystatin A1 The spectral ... comparison of the fivepolyenes macrolide solution structures. To illustrate this, wehave represented in Fig. 4 (right) the overlays of the different NMR ensembles. The structures are seen from the ... is independent of the solvent and relies on the structure of the macrolide itself. The common struc-tural feature is then likely conserved when the polyenesare transferred from the aqueous compartment...
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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt
... solved the crystal structure of another asco-laccase, from Thielavi-a arenaria (TaLcc1), at 2.5 A˚resolution. The loops near the T1 copper,forming the substrate-binding pockets of the two ... attached to the T2 copper, as observed in the crystal structure of MaL. The unique fea-ture of TaLcc1 and MaL as compared with other laccases structures isthat, in both structures, the processed ... redox potential(E°) of the substrate must be low enough, as the rate of the reaction has been shown to depend on the dif-ference between the redox potentials of the enzymeand the substrate (DE...
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