Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

... mecha- nism of transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformers of the solu- tion structure ... second- ary structure elements. As in other ribotoxins, these A B C Fig. 2. Representation of the 3D structure of HtA in solution. (A) Superposition...

Ngày tải lên: 18/02/2014, 08:20

... effect. Description of the toxin structure and potential surface The characteristic NOE connectivities, reported in Fig. 3A, and the analysis of the / and w angle distribution allowed the identification of the ... )1 topology [47] of the triple-stranded antiparallel b-sheet was Fig. 3. Summary of data used in the determination of the secondary structure of c...

Ngày tải lên: 20/02/2014, 11:20

... and contacting the DNA backbone. The solution structure of the MBD of MBD1 shows high similarity to that of MeCP2 except for the C-terminus [18]. At the C-terminus of the MBD, MeCP2 exhibits ... (c )MeCP2] [15]. The solution structure of the MBD of rat (r )MeCP2 has recently been determined [17]. The MBD adopts a wedge- shaped structure, composed o...

Ngày tải lên: 21/02/2014, 00:20

... accumulation of the toxin by the food chain in the organisms living close to the zoan- thid colonies [3]. It has been reported that dinoflagellates of the genus Ostreopsis are the most probable origin of ... palytoxin action against the actin cytoskeleton (Fig. 3). At present, in spite of the impor- tance of the unpolymerized actin pool for the mainte- nance of...

Ngày tải lên: 18/02/2014, 14:20

... consumption of the algae by the shellfish, PTX-2 can be metabolized to other PTX derivatives. In the digestive gland of the scallop P. yessoensis, the C43 methyl group in PTX-2 is oxidized to the alcohol (PTX-1), ... supports the idea that lactone ring integrity is essential for the action of PTXs; oxidation on C43 decrease the toxic- ity of the molecule, and oxidat...

Ngày tải lên: 18/02/2014, 14:20

... in the Electronics domain. Likewise, in the Book+Kitch. set, “stainless” rarely appears in the Book domain and “interest” does not occur often in the Kitchen domain and they are grouped under the ... to the in -domain gold standard. The last row shows the average loss over all the four domains. Parameter Sensitivity There is only one parameters to be set in the JST-...

Ngày tải lên: 20/02/2014, 04:20

... along the horizontal axis was used to convert the left structure to the right structure. The N-ter- minus is at the left for every structure. The best-fit overlays of the 10 lowest overall energy structures ... [1]. The 18.5 kDa isoform of myelin basic protein (MBP) is one of the most abundant proteins in CNS myelin; MBP maintains the compaction of the sheath...

Ngày tải lên: 19/02/2014, 07:20

... (B) structure alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII. Fig. 6. Structure of a representative folded conformer of AII ... quantitative comparison of the structure of AII in solution with the X-ray structure of AII complexed to the Fab131 mAb. In Fig. 7A, a sequence alignme...

Ngày tải lên: 20/02/2014, 23:20

... bond between the hydrogen of OH9 (H O 9) and the oxygen of OH7 (O H 7) which can contribute to the stabilization of the C7–C9 region of the macrolide. Structural analysis of nystatin A1 The spectral ... comparison of the five polyenes macrolide solution structures. To illustrate this, we have represented in Fig. 4 (right) the overlays of the different NMR ense...

Ngày tải lên: 21/02/2014, 03:20

... solved the crystal structure of another asco-laccase, from Thielavi- a arenaria (TaLcc1), at 2.5 A ˚ resolution. The loops near the T1 copper, forming the substrate-binding pockets of the two ... attached to the T2 copper, as observed in the crystal structure of MaL. The unique fea- ture of TaLcc1 and MaL as compared with other laccases structures is that, in both...

Ngày tải lên: 14/02/2014, 18:20