Tài liệu Báo cáo khoa học: Histones in functional diversification Core histone variants pdf

... variants. Variants of core histones in various nuclear processes Histone variants might act as ‘control panels’ in regu- lating all DNA-related processes. Minor histone variants are now becoming known as ... also be involved in demarcating functional regions of the chromatin. We discuss in this review why two of the four core histones show higher variation. A comp...

Ngày tải lên: 20/02/2014, 02:22

... general unfolding, not leaving any hydrophobic cleft for bis-ANS binding. High pressure is well known to denature proteins to partially folded states [15,17,38,48–50]. The large increase in bis-ANS binding ... cavities, one in the hydrophobic core (M88V) and the other in the protein–RNA interaction (T45S), decrease the stability of the capsid. Our findings illuminate the role of packin...

Ngày tải lên: 19/02/2014, 12:20

... cGMP binding [13], and, in PDE6, both of the amino acids corresponding to Phe433 ⁄ Asp434 in rPDE2A are required for cGMP binding [14]. Our initial mutations in cyaB1 GAF B also involved individual ... major interaction site for the adenine moiety. In b1, an arginine residue (Ile417 in rPDE2) binds to N1 and a threonine (Ser419 in rPDE2) inter- acts with N7 and the N 6 amino group...

Ngày tải lên: 19/02/2014, 02:20

... a deepening of the lines be- tween the eyebrows, indicating concentration, deter- mination, opposition or hostility.” Definitions of this kind are again not easily handled in machine opera- ... adequate for our purposes. In giving a synonym definition, we are making use of a more general idea, namely, that of defining the intra- linguistic meaning of a word in terms of its relation...

Ngày tải lên: 19/02/2014, 19:20

... FUÆlgprotein )1 Æh )1 ). In parallel with this decrease in activity, oxidized proteins accumulated in the matrix upon aging while the CML-modified protein content assessed by ELISA significantly increased ... been found in several mammals including human tissues and cell lines [24–26]. It is responsible for the degradation of abnormal proteins and certain short-lived specific proteins [2...

Ngày tải lên: 20/02/2014, 11:20

... specialized to a domain by inheriting and instantiating domain-specific types and instances of the PS objects. 5.3 Adaptive Turn Planning The fission component comprises detailed con- tent planning, media ... the multi-modal setting. Novel aspects in turn planning and realization include the comprehensive modeling in a sin- gle, OWL-based ontology and an extended range of context-sensitive...

Ngày tải lên: 20/02/2014, 12:20

... found in a writ- ten text. extended in order to maintain a coherent discourse structure for the modelling of the producer. Thus rhetorical relations describing planning processes are introduced. ... containing (U2) and (U3) is 'cut off' and not available for further attachment. Embedded within the expectation is an utterance describing the ongoing planning and searchi...

Ngày tải lên: 20/02/2014, 18:20

... geography, most questions within the English subset are answered in well under one second, including queries which involve taking Joins between relations having of the order of a thousand ... formalisms, in that it permits data to be defined by general rules having the power of a fully general programming language. The logic programming approach therefore allows one to interfac...

Ngày tải lên: 21/02/2014, 20:20

... the message generator is in generic mode, it b constrained to locating generic links during step 2 of the cycle, and it is constrained to selecting the generic schema during step 3 of the cycle. ... links linking each of the intermediate facts to their subfacts. Total.user-disk- space is a newly created intermediate fact, and a relational link, with rrelation percent, is created linki...

Ngày tải lên: 21/02/2014, 20:20

... better integrated into centering than the caching model, since the cells of segment struc- tures simply contain "pointers" that implement a direct link to the original centering data. ... mine the "segment focus", since that is implicitly given in the local centering data already available in our model. A recent attempt at introducing global discourse no- tions i...

Ngày tải lên: 22/02/2014, 03:20