Tài liệu Báo cáo khoa học: Antiplasmin The forgotten serpin? doc

... in the literature with respect to the amino-acid numbering of the AP protein although there is general agreement that the signal peptide cleavage occurs at the Asp-Met bond 27 resi- dues from the ... truncated at the C-terminus by at least the final 26 amino acids. When this observation is taken together with the fact that 70% of antiplasmin is in the Asn12 cleaved form w...

Ngày tải lên: 20/02/2014, 02:21

Ngày tải lên: 18/02/2014, 16:20

... mitochondrial matrix, the transmembrane helix and the following  20 residues) is crucial to determin- ing the aggregation state of these proteins. The data therefore support the hypothesis that this ... close to the N-terminal trans- membrane helix anchoring the protein to the inner membrane of mitochondria [27]. Therefore, the N-ter- minal segment (containing the residue...

Ngày tải lên: 14/02/2014, 18:20

... cOHB-modification of the C-terminal domain in the periplasm on the transition to the large-pore conformation In order for the large pore to form, a substantial portion of the hydrophilic C-terminal ... cOHB-modification of the C-terminal domain in the periplasm would increase the hydropho- bicity of hydrophilic segments in this domain, and thereby enable them to be incorporate...

Ngày tải lên: 18/02/2014, 04:20

... in the refinement. The correctness of the model was checked using the procheck [43] and whatcheck [44] programs. The coordinates of the higher-resolution complex models have been deposited in the ... between the free and the bound forms. In the latter case, the line broadening caused by the dynamic process could be extremely large and unspecific, preventing the detecti...

Ngày tải lên: 18/02/2014, 16:20

... explaining the A B DE C Fig. 3. (A) The homology model of the AtdA3, with the substrate binding pocket residues highlighted in red and the docked substrate 2EA in gray. (B,C) The position of the substrate, ... sur- faces of the substrate channel leading to the binding pocket of the WT AtdA3 (D) and the mutant I248L (E). The substrate posi- tions are simulated using th...

Ngày tải lên: 19/02/2014, 02:20

... indicated, the assay was initiated by the addition of the enzyme preparation to an otherwise complete assay mixture. The reaction was stopped after 0–30 min by mix- ing a portion of the incubation ... glucuronate 1-phosphate [5,6]. However, neither the pyrophospha- tase nor the phosphatase implicated in these reactions has been identified. Furthermore, other mechanisms, in which...

Ngày tải lên: 19/02/2014, 07:20

... dehydrogenase, which weremeasuredtogetherinthesameassay.Thedataindicate that the p resence of propionate in the medium reduces the activity by % 50% in the w ild-type as well a s in the DmcsA strain. T herefore ... coli the 2-oxo acid is further oxidized to acetyl-CoA, which is either funnelled i nto the citrate cycle or used for biosyntheses [7]. A clue to the mechan ism of p...

Ngày tải lên: 19/02/2014, 16:20

... both the source and target side. On the source side, the fea- tures include the verbal predicate, the semantic role of the argument, the head word and the boundary words of the argument. On the ... argument. On the target side, the trans- lation of the verbal predicate, the translation of the head word of the argument, as well as the boundary words of the t...

Ngày tải lên: 19/02/2014, 19:20

... are highly related to the observed words. Therefore, missing words can be used to prune the hypotheses that are also highly related to the missing words. Consider the hypotheses of latent vectors ... Semcor. We tune the parameters in wmfvec and other base- lines based on SE2, and then directly apply the tuned models on other three data sets. Data: The sense inventory is WN3.0 fo...

Ngày tải lên: 19/02/2014, 19:20