Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt

... EC, endothelial cell; FGF, fibroblast growth factor; HIF, hypoxia-inducible factor; PlGF, placenta growth factor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor ... dependent on the vascular endothelial growth fac- tor ⁄ vascular endothelial growth factor receptor (VEGF ⁄ VEGFR) system [1,2], and the further de...

Ngày tải lên: 18/02/2014, 11:20

... Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms Eric Sulpice 1 , ... VEGF, and compared the mechanisms by which PF -4 i nhibits the DNA synthesis induced by VEGF 165 and VEGF 121 . The DNA synthesis induced by VEGF 165...

Ngày tải lên: 19/02/2014, 16:20

... the vicinity of the S1 pocket [11, 34] , in the first part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areas that are stabilized by TF [9,25,26]. The ... from the FVIIa molecule that is present in the active conformation of both the free and TF-bound form, rather than shifting the equilibrium between the zymogen-l...

Ngày tải lên: 18/02/2014, 08:20

... mgÆmL )1 poly(U). The factor mix contained 8.0 l M [ 14 C]Phe-tRNA Phe (44 c.p.m. per pmol), 112 n M active EF-G, 40 n M active EF-Tu and 0–8.0 n M EF-Ts. The ribosome mix and the factor mix were incubated ... D 42 0 value of the culture at the interception point between the exponential and the Ôstarvation phaseÕ of growth, is 78% of the point of growth inhib...

Ngày tải lên: 21/02/2014, 00:20

... followed by 35 cycles of 94 °C for 30 s, 58 °C for 30 s and 72 °C for 30 s. The sizes of the PCR products were confirmed by 2.0% agarose gel electro- phoresis and further confirmed by the direct ... standard. Isomerohydrolase activity was calculated from the area of the 11cROL and 13cROL peaks and expressed as the mean ± SD of three independent measurements. Retinal...

Ngày tải lên: 14/02/2014, 14:20

... elastase, MIP-2, and TLR -4 expression during human and experimental sepsis. Shock 23, 39 44 . 30 Chaluvadi MR, Nyagode BA, Kinloch RD & Morgan ET (2009) TLR4 -dependent and -independent regula- tion ... showed a marked decline at 24 h after CLP, and the reduction was atten- uated by GdCl 3 (Fig. 4) . Hepatic TLR2 and TLR4 protein expression The hepatic level of TLR2...

Ngày tải lên: 14/02/2014, 18:20

... deprivation- induced apoptosis. J Immunol 177, 244 1– 245 1. 4 Alvarado-Kristensson M, Melander F, Leandersson K, Ro ¨ nnstrand L, Wernstedt C & Andersson T (20 04) p38-MAPK signals survival by phosphorylation ... Ser112, Ser136 and Ser155 [86]. The dissociation of Bax and Bad from 14- 3-3 is pro- moted by JNK via phosphorylation of 14- 3-3 at Ser1 84; this reduces the af...

Ngày tải lên: 14/02/2014, 22:20

... FEBS second site). The measured enthalpy is the sum of two terms: the reaction enthalpy, independent of the buffer used in the experiment, and another term representing the contribution of the proton ... binding affinity by 100-fold and the lifespan of the complex by 10-fold, as judged by k off . The physiological chaperone cycle probably consists of the rapid...

Ngày tải lên: 16/02/2014, 14:20

... splicing around the 5¢-end of exon 6 of Meis2 and Meis3 was tested by RT-PCR. The positions of molecular mass markers are shown to the left, and the size in base pairs of the products to the right (the Meis2 ... analyzed by western blot (WB) with a GBD antibody. The specific full-length bands are indicated by arrows. The numbers below the lanes correspond to the...

Ngày tải lên: 16/02/2014, 15:20

... bond between the stefin A A49 amide and cathepsin B G 24 carbonyl. The binding of this loop is further stabilized by a hydrogen bond between the stefin A N52 side chain amide and the cathepsin B S25 ... activ- ity, nor the inhibition of the enzyme by their endoge- nous protein inhibitors cystatins and stefins [21]. A further step in understanding of these mechanisms was...

Ngày tải lên: 18/02/2014, 04:20