Tài liệu Báo cáo khoa học: Chromokinetics of metabolic pathways doc

... also in large metabolic pathways. 2754 J. W. Stucki (Eur. J. Biochem. 271) Ó FEBS 2004 Chromokinetics of metabolic pathways Jo¨ rg W. Stucki Department of Pharmacology, University of Bern, Bern, ... bottom-up instead of a top-down approach, as used above. The advantage of this has to do with the basic organization of metabolic pathways, which seem to resemble a collec...

Ngày tải lên: 19/02/2014, 13:20

... compare one set of classes against an- other and are also not very reliable estimates of the quality of a set of classes. It is clear that a formal evaluation scheme would be of great help. ... the aspect of evahiating the obtained clusters against classes provided by human experts. 2 The Need Although there has been a lot of work done in ex- tracting semantic classes o...

Ngày tải lên: 20/02/2014, 22:20

... period of observation in the presence of both ATP and Ca 2+ were excluded from the following analyses. Visual characteristics of the Albers–Post scheme The number of peaks (i.e. the number of up–down conformational ... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy- ses of SERCA were performed with the...

Ngày tải lên: 14/02/2014, 14:20

... the inhibition of CYP activity observed in the absence of changes in protein expression in rabbit he- patocytes [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing ... hepatic mRNA level of CD163 compared to that of sham group. Twenty-four hours after cecal ligation and puncture (CLP), the hepatic mRNA level of CD163 was similar with that of the s...

Ngày tải lên: 14/02/2014, 18:20

... only after partial unfold- ing of the a-helix from the body of the b-sheet (Fig. 2C). Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... determine the pathways to which different conformations belong. However, our understanding of the importance of different parts of the molecule and their flexibility in the process...

Ngày tải lên: 14/02/2014, 18:20

... solu- tion of ThT and the fluorescence intensity of the solu- tion was measured at 482 nm. Figure 4A shows the kinetics of aggregation of a-synuclein in the presence of 100 lm MPTP and the effect of 50 ... Admin- istration of MPTP has also been shown to form aggregates of a-synuclein in nigral neurons of baboons (Papio anubis) [11]. Depletion of a-synuclein was maxi- mum in...

Ngày tải lên: 14/02/2014, 19:20

... pore (PTP) [1,2], is of a sufficient size (cut-off of $ 1.5 kDa) to allow the pas- sage of solutes and water, which may also result in rupture of the outer membrane. The identity of the proteins comprising ... deamination [30]. The lack of oxida- tion of 1 mm glutamate in the presence of 5 mm succinate can be demonstrated by a complete lack of effect of rotenone on recordin...

Ngày tải lên: 14/02/2014, 19:20

... interaction of both proteins or by binding of CagA PY to Csk, a negative regulator of Src [6,7]. Because Src is the primary kinase phos- phorylating CagA in the EPIYA-motifs, inhibition of Src by ... the disrup- tion of cell–cell junctions, a loss of cell polarity and the induction of pro-inflammatory and mitogenic responses (Fig. 3C). The first detected interaction part- ner of...

Ngày tải lên: 14/02/2014, 19:20

... several pathways, including the transloca- tion of Bax to mitochondria, and CHOP-regulated inhibition of the expression of antiapoptotic proteins, such as Bcl-2 [23,39]. A schematic representation of the ... presence of relatively low amounts of oleate protected cells from stearate-induced toxicity and restored the ability of the cells to accumulate triacylglycerols. Our data s...

Ngày tải lên: 14/02/2014, 22:20

... presence of increasing DP may be a common feature of glucansucrase. Additional studies are required to elucidate the dex- tran-dependent synthesis of glucan. As the affinity of the GBd of GTF-I ... Separation of nigerooligosaccharides by acti- vated carbon chromatography. Doc. S1. Simulation of the glucan synthesis reaction. This supplementary material can be found in the online...

Ngày tải lên: 14/02/2014, 22:20