Tài liệu Báo cáo khóa học: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism doc

... Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism Marcel Amichot, Sophie Tare ` s, ... this area, including helix J, is important for the structure and activity of CYP6A2. Furthermore, we show here that point mutations in a cytochrome P450 can have a prominent role in insecticide...

Ngày tải lên: 19/02/2014, 12:20

... tried to link the expression of AP-2a in these tissues to upstream signaling pathways. They assessed the organization of a cis-regulatory region within the fifth intron specific for directing AP-2a ... at the C-terminus shown in blue medi- ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical in all sequences in the a...

Ngày tải lên: 16/02/2014, 09:20

... strains revealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was substituted by thymine and none of the other sites ... the mutation in the 3D structure The results of the sequence alignment within the ACAD family revealed that the mutated residue in the sku mutant was strict...

Ngày tải lên: 18/02/2014, 04:20

... for the premature decline of the enzyme activity in the course of the assay. The amido- lytic assay was performed with plasmin pre-incubated with stearate and reaction products. If the pre-incuba- tion ... 1-4 plasmin) con- tains the kringle 5 and the catalytic domain of plas- min, whereas microplasmin (des-kringle 1-5 plasmin) is composed of the catalytic domain only...

Ngày tải lên: 18/02/2014, 17:20

... chemokines stimu- lated mainly by in ammatory cytokines, including IL-1b, TNF-a and IFN-c. (B) Chemokines expressed in the joint recruit leukocytes into the joints. In addition to functioning in ... a G-protein that transduces the intracellular signal. The two major subclasses include the CC chemokines (where the cysteines are neighboring) and the CXC chemokines (where t...

Ngày tải lên: 18/02/2014, 18:20

... CD36. The accumulation of lipid in these macrophages is accompanied by increased endocytosis and degradation of apoB, with the difference in the rates of the latter two processes resulting in accumula- tion ... consistent with poor cellular handling of the glycated apoB protein. This may be partly explained by the resistance of the modi- fied apoB to degradation by ly...

Ngày tải lên: 19/02/2014, 02:20

... [281], exhibiting insign ificant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal flavoprotein fragment in the single polypeptide chain structurally resembling NADPH -P450 ... the N-terminus in the engineered hemoprotein [315]. Similar observations wer e mad e with the CYP102 congener [47]. In accord with these findings, threonin e...

Ngày tải lên: 19/02/2014, 16:20

... euge- nin, indicating that eugenin is indeed acting through CCK 2 receptors. To further investigate the interaction of eugenin with CCK 2 receptors, we investigated the effect of eugenin on lymphocyte ... agents in her milk, there may be host defence compounds in the secretion contained in the pouch, or there may be host defence compounds in the saliva, which she deposits...

Ngày tải lên: 19/02/2014, 16:20

... bands corresponding to all thymines in the )11 … +2 pro- moter region came up clearly in the footprints obtained even at 13 °C and the lowest oxidant dose applied and in the absence of MgCl 2 . In the foot- prints ... because the magnitude of the Mg effect increases progressively as the temperature falls (Table 1), which may be due to increased binding of Mg 2+ . This...

Ngày tải lên: 19/02/2014, 18:20

... parse of that string with a PCFG approximation to the adaptor grammar. This PCFG contains a production for each adapted subtree in the parses of the other strings in the training corpus. A final ... grammar, in which the subtrees are specified in advance, in an adaptor grammar the subtrees, as well as their probabilities, are learnt from the train- ing data. In order...

Ngày tải lên: 20/02/2014, 09:20