Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc

... effect of increasing concen- trations of native and oxidized elafin and trappin on the activity of a constant concentration of NE and Fig. 1. Inhibition of neutrophil elastase (NE) and proteinase ... residues (M25 and M51 for elafin, and M63 and M89 for trappin). M25 and M63 are the P 1 ¢ residues of the inhibitors’ active centers. Mass spectro- metry of the two p...

Ngày tải lên: 19/02/2014, 07:20

... compilation ª 2007 FEBS Binding of N- and C-terminal anti -prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrP C ) obtained from human, sheep, cattle and mouse Thorsten ... for human, sheep, cattle and mouse. The calculation is composed of signals from the N-ter- minal binding antibodies SAF34, P4...

Ngày tải lên: 19/02/2014, 02:20

... measure- ments of the reduction potentials of proteins involved in complexes have been reported [5–7], but the effect of partner binding on the microscopic properties of the redox centres in proteins ... the binding of Zn-rubredoxin. Overall, the two sets of results reported show that phosphate binding and docking with the Zn-rubredox- in has a very limited effect on t...

Ngày tải lên: 19/02/2014, 17:20

... user of long-chain fatty acids making a brain-specific isoform intriguing. CPT1c was identified and cloned from in silico sequences as a highly homologous member of the CPT1 class of enzymes and ... directly upon endocrine signals, although endocrine factors can impinge on its activity. Thus, the activity of ACC is an indicator of energy surplus and is thought to be one of t...

Ngày tải lên: 14/02/2014, 22:20

... the structures of PSs from E. coli and M. tuberculosis. Structural analyses Analysis of the sites of substrate binding from NMR data, and structural comparison of the E. coli, M. tuberculosis and A. ... suggests that binding of pan- toate and ATP preserves the dimer symmetry in solu- tion. In an effort to unambiguously identify and understand the nature of bindi...

Ngày tải lên: 16/02/2014, 09:20

... study of FVIIa [13], and investigated the effects of the mutation on the enzymatic maturation of FVIIa and on the response of FVIIa to TF. Our measurements, in both the presence and absence of TF, ... subsites, of A B Fig. 5. Structure of FVIIa and model of G372A-FVIIa. (A) Energy- minimized structure of FVIIa. Representation of the part of FVIIa discussed in the...

Ngày tải lên: 18/02/2014, 08:20

... the membrane localization of proteins will facilitate the formation of protein com- plexes and increase reaction rates [35]. To mimic the in vivo situation, Src and other proteins can be embed- ded ... loops and occur at constant activities of Src inhibitors and activators, such as C-terminal Src kinase and receptor- type protein tyrosine phosphatases. We demonstrate...

Ngày tải lên: 18/02/2014, 11:20

... purification of tissue inhibitor of metallo- proteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue ... Loennechen 1 and Jan-Olof Winberg 2 1 Department of Pharmacy, University of Tromsø, Norway 2 Department of Medical Biochemistry, University of Tromsø, Norway 3 School o...

Ngày tải lên: 18/02/2014, 11:20

... coordi- nating proteins. Iron–sulfur clusters are one of the most ancient and versatile cofactors of several impor- tant class of proteins and have been implicated in vari- ety of functions [29,30]. Iron and ... scavenging of free radicals and the reactivation of degenerated proteins during infection by a family of proteins named ‘thio- redoxins’ is one of the e...

Ngày tải lên: 18/02/2014, 12:20

... values of 60 kDa and 120 kDa (Fig. 3B). Similarly, the purified protein BHAb was eluted from Superdex 200 (data not shown) Fig. 2. Effect of camalexin and 3-phenylindole on the activity of BH from ... suggest that BHs from L. maculans and A. brassicicola belong to the amidase-signature super- family of proteins that contain the Ser ⁄ Ser ⁄ Lys triad active site. Protei...

Ngày tải lên: 18/02/2014, 14:20