... targets).Effects of DNA cis-platination on sequence-specific DNA binding of p73 proteinsWe tested the influence of DNA modification withcisplatin on the binding of two p73 isoforms, p73d andp73b, ... stability of the p53 DNA complexes [10].In addition, interactions of the p53 protein with cer-tain response elements can be controlled by changes in DNA topology inducing formation of non-B DNA structures ... activity of the drug [26,29,30].Interactions of the p53 protein with cisplatin-modi-fied DNA (cisPt -DNA) have recently been studied [31–36]. In the absence of the p53DBS, enhancement of p53 sequence-nonspecific...