Tài liệu Báo cáo khoa học: Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells docx

... of Caveolin-1 and P2X 7 distribution in control and in Caveolin-1 shRNA-transfected E10 cells. Note the loss of colocalization of Caveolin-1 and P2X 7 in Cav-1 shRNA treated cells. Caveolin-1 and ... independent channels (Fig. 5). Caveolin-1 and P2X 7 receptor are endogenously expressed in E10 cells, and their localiza- tion in subconfluent cells was det...

Ngày tải lên: 19/02/2014, 00:20

... in plasmin formation, to a decrease in plasmin binding or to a combination of the two. We demonstrate that both mAb 34D3 and mAb A10.2 inhibit plasmin binding to cells (Fig. 5A) and fibrin (Fig. 5B) in ... function. Blocking the kringle 1 lysine- binding site with monoclonal antibody 34D3 fully abolished binding and activation of Glu-plasminogen and prevented both fibrinolysis...

Ngày tải lên: 20/02/2014, 01:20

... Dashed lines indicate van der Waals contacts with interatomic distances in A ˚ . Dotted lines indicate C-HÆÆÆO interactions. Black lines indicate interac- tions in SQV complexes. Red lines indicate interactions ... hydrophobic interactions in proteins [26]. Removing a methyl group in the protein hydrophobic core affects protein folding and decreases the protein stability in mutant...

Ngày tải lên: 18/02/2014, 04:20

... stromal cells are diffi- cult to distinguish from those involved in wound heal- ing and in ammation. In association with cancer growth, the stromal cells grow and expand to release many glycoproteins ... have included a full list of N-glycopro- teins from C. elegans and a partial list from mouse liver containing the protein (gene) ID, protein name, glycosy- lated sites, and...

Ngày tải lên: 16/02/2014, 08:20

... 2009) doi:10.1111/j.1742-4658.2009.07438.x Glial cells, especially astrocytes, are not merely supportive cells, but are important partners to neighboring cells, including neurons, vascular cells, and other glial cells. Although glial cells ... from astrocytes The P2 receptors responsible for increases in [Ca 2+ ] i in astrocytes are well characterized, and G-protein-cou- pled P...

Ngày tải lên: 16/02/2014, 09:20

... the MuvB proteins Lin-37, Lin-52, Lin-54 and chromatin- associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48. Furthermore, A-Myb and B-Myb were present in immunoprecipitations for Lin-9, Lin-37 and Lin-54 [90,92]. ... such as cyclin A and cyclin B1, in dividing cells [92]. Furthermore, depletion of Lin-9 and B-Myb in p53 ) ⁄ ) MEFs caused lowered expression of cyclin A, cyclin B...

Ngày tải lên: 16/02/2014, 09:20

... chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and the receptor- binding domain. The C and T domains remain covalently linked ... Following binding to its cell-surface receptor, diphtheria toxin is internalized through the clathrin-coated pathway. The acidic pH in the endo- some triggers a conformational c...

Ngày tải lên: 16/02/2014, 09:20

... lgÆmL )1 (lines 4–6). (C) Increased binding of pH 4 buffer- exposed IVIg to recombinant human IFN-c. (D) Increased binding of low-pH buffer-exposed IVIg to human factor H. In both panels, binding of ... antigen-binding specificities (Fig. 1B). Enhanced binding of low-pH buffer-exposed IVIg to recombinant human interferon-c (IFN-c) and other self-antigens Interactions of IVIg with cytokines...

Ngày tải lên: 16/02/2014, 15:20

... changes in ligand- binding stoichiometry and affinities. The removal of a disulfide bond in rat lipocalin-type prostaglandin D synthase slightly increased the binding affinity for bio- logical ligands, ... upon ligand binding. Indeed, high T 1 ⁄ T 2 ratios were observed for Tyr9 and Gln11 (strand A), Arg32 (helix II), Val90, Lys92, and Glu94 (strand G), Phe96 and Ser97 (strand H), Ph...

Ngày tải lên: 18/02/2014, 06:20

... for developing a screening system to identify and charac- terize candidate insecticidal compounds showing both inductive and potentiative activity. Results The DNA-binding domains (DBDs) of Leptinotarsa and ... linker region and ligand-binding domain (LBD) of ecdysone receptors. Fig. S2. Amino acid alignment of linker region and ligand-binding domain (LBD) of ultraspiracle ⁄ RXR rec...

Ngày tải lên: 18/02/2014, 08:20