Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx

... 1. The effect of tyrosine phosphorylations on the binding affinity of ephrinB2 (301 –333) to the SH2 domain of Grb4 and to the PDZ domain of PDZ-RGS3. In the combination experiments, the two C terminal ... PDZ binding on the interactions of the Grb4-SH2 domain with the ephrinB2 (301 –333)-pY304 peptide. (A) The PDZ- binding curves are for the fluorescein-labeled...

Ngày tải lên: 19/02/2014, 12:20

... domain deletions are more com- mon at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein and the ... C−terminus Length of the N terminus in % of the deleted domain Length of the C terminus in % of the deleted domain Pfam, N−terminus Pfam, C −terminus Number...

Ngày tải lên: 19/02/2014, 07:20

... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the ami- noquinol intermediate ... benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine (Fig. 5B) suggests differences in binding of the two substrates within the active site of th...

Ngày tải lên: 19/02/2014, 07:20

... potential of the haem, rate constants o f CO, O 2 and CN b inding to haem, and CD spectra in the Soret region [15–18], suggesting that this residue is critical for maintaining the electronic states of ... ncubated for 10 min prior to spectroscopic measurements. Cyanide binding The association rate of cyanide to haem was observed by monitoring changes at 417 nm in spectra...

Ngày tải lên: 19/02/2014, 16:20

... fetus and in regulating immune responses within the intestine. Induction of fgl2 in macrophages in response to viruses results in the production of a potent coagulant activity with the charac- teristics ... shown in Table 2 and Fig. 5. Arrows indicate the bands that are interacting with these probes. All the lanes have labelled probes. The adding of extracts and co...

Ngày tải lên: 20/02/2014, 11:20

... pointing in opposite directions. The stabilization of the folded conformation can be explained by the stacking of the Val3 side chain with the Pro7 ring and by a hydrophobic cluster formed by the ... possibly the result of twisting or bending in the middle of the amino-acid sequence of the hormone [49]. Structure calculations and analysis The presence of...

Ngày tải lên: 20/02/2014, 23:20

... malfunction of this Cbl binder hampers the uptake of the minute amounts of the vitamin present in food. Only around 1% of the ingested Cbl can be absorbed by passive diffusion [6]. Classical vitamin B 12 deficiency ... sequence of mature IF. Approximately one-third of the protein was cleaved at the internal site …PSNPflGPGP. The key properties of the preparation...

Ngày tải lên: 21/02/2014, 00:20

... and mine it very deeply, not necessarily discovering every aspect of the domain but requiring that the various aspects be integrated with one another to produce a coherent whole. Even in the ... of our art? Instead of assuming that the problem is one of using typed English to access and/or update a file or files in a single database system, let us define a spectru...

Ngày tải lên: 21/02/2014, 20:20

... structural role in the proper folding and disulfide bonding in insulin [2]. After proinsulin cleavage, it is released to the blood together with insu- lin in equimolar amounts. The 31-residue peptide ... C-peptide in SDS solution represent the remaining population of NMR-visible monomers because the increasing fraction of oligomers (with increasing SDS concentration) does...

Ngày tải lên: 18/02/2014, 04:20

... modules: the DNA-binding domain (DBD) at the amino-terminus and the oligomerization domain in the central region of the protein [1,4]. The HSF DBD belongs to the ‘winged’ helix-turn-helix family of DNA-binding ... Unlike other winged helix-turn-helix proteins, the wing of the HSF does not appear to contact the DNA. The wing of the Saccharomyces HSF is necessa...

Ngày tải lên: 18/02/2014, 04:20