Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx

... original French government works 1 Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells 3 Emilie Roudier*, Christine Bachelet and Anne Perrin Unite ´ de ... investigated in hepatocellular carcinoma HepG2 cells cultivated with or without pyruvate during and after hypoxia. In the present study, we sho...

Ngày tải lên: 18/02/2014, 16:20

... actually involved in DNA binding. Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA- binding protein (SSB) and human replication protein A (RPA) [23,24], ... significant defects in ssDNA binding and dsDNA binding A B Fig. 3. The DNA binding activities of the Rad51 mutants. (A) The ssDNA binding experiments. The /X174 circular ssDNA (40...

Ngày tải lên: 19/02/2014, 06:20

... enrichment in iNOS activity within the particulate fraction of epithelial cells. Apical distribution of iNOS in intestinal epithelial cells To get more insight into the localization of iNOS in intestinal ... to apical domains of intestinal epithe- lial cells. Particulate fraction association of iNOS in vivo In order to determine the distribution of iNOS in intestinal epithel...

Ngày tải lên: 19/02/2014, 16:20

... conjunction prefix (+ +w and ) and a pronominal possessive suffix ( + +y ‘my’). In our approach, tokenizing and morphologically tagging (including part-of-speech tagging) are the same operation, ... of the development and test corpora, and 120,000 words in each of the train- ing corpora. We will refer to the training corpora as TR1 and TR2, and to the test corpora as, TE1 and...

Ngày tải lên: 20/02/2014, 15:20

... Malaysia, envy in Belgium, love and happiness in Japan; red is associated with luck in China and Denmark, but with bad luck in Nigeria and Ger- many and reflects ambition and desire in India. Some ... their messages and convey emotions in natural interactions (Jacobson and Bender, 1996; Hardin and Maffi, 1997). Colors are both indica- tive of and have an effect on...

Ngày tải lên: 22/02/2014, 02:20

... based on the values obtained for alanine, threonine, glycine, valine, phenylalanine and aspar- tate. The analysis, starting from protein hydrolysis, was performed in quintuplicate. Activity assays For ... protein–ligand inter- actions were generated using LIGPLOT [37] based on Vandermarliere et al. [12]. Amino acid residues that form direct protein–ligand interactions with their main chai...

Ngày tải lên: 14/02/2014, 19:20

... mitochon- dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3, the phosphoserine ⁄ threonine binding proteins in the cytosol. 14-3-3 prevents Bax and ... discuss DNA fragmentation and protein phosphorylation, focusing on caspase and serine ⁄ threonine protein phos- phatase activation. Abbreviations AIF, apoptosis-inducing fa...

Ngày tải lên: 14/02/2014, 22:20

... is typically in the range 2–3 mm [26]. Finding experimental evidence that electrical cou- pling is the key ‘spring’ interlinking the Ca 2+ stores has involved repeating the decoupling experiment ... pendulums are randomly set to swing, over time, interactions through the springs result in the appearance of a global synchrony pattern involving all the pendulums. Fig. 1. Central interruptio...

Ngày tải lên: 16/02/2014, 09:20

... Dashed lines indicate van der Waals contacts with interatomic distances in A ˚ . Dotted lines indicate C-HÆÆÆO interactions. Black lines indicate interac- tions in SQV complexes. Red lines indicate interactions ... hydrophobic interactions in proteins [26]. Removing a methyl group in the protein hydrophobic core affects protein folding and decreases the protein stability in mutant...

Ngày tải lên: 18/02/2014, 04:20

... levels and collagen release into culture medium induced by a-defensin-1 and a-defen- sin-2. Knocking-down b-catenin using small interfering RNA technology also prevented a-defensin-induced increases ... fibroblasts were examined. We found that a-defensin-1 and a-defensin-2 induced dose- dependent increases in the incorporation of 5-bromo-2¢-deoxy-uridine into newly synthesized DNA i...

Ngày tải lên: 18/02/2014, 06:20