Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx
Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx
... 7411
Mixed lineage leukemia histone methylases play critical
roles in estrogen-mediated regulation of HOXC13
Khairul I. Ansari, Sahba Kasiri, Imran Hussain and Subhrangsu S. Mandal
Department of ... presence of E2. Binding of ERa and ERb
was increased in both ERE1 and ERE2 of the
HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of
E2-induced binding of...
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx
... brahma; CBP, CREB-binding protein; EcR,
ecdysone receptor; HAT, histone acetyl transferase; H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL, mixed lineage
leukemia; MOF, male absent ... revealed several histone meth-
yltransferases (HMTs) involved in the K methylation
of histones H3 and H4 with crucial roles in maintain-
ing normal cellular functions in e...
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
...
RING
SET
Fig. 2. Domain structures of mixed lineage leukemias (MLLs). AT-hook is a DNA-binding domain. Bromodomains (BROMO) are involved in
the recognition of acetylated lysine residues in histone ... multiple lines of
evidence indicate that MLLs play critical roles in
cell-cycle regulation.
In addition to cell-cycle regulatory genes, MLL1
plays important roles...
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... & Pharmacy, Institute of Pharmaceutical Biology, Goethe-University of Frankfurt ⁄ Main, Germany
Mixed lineage leukemia fusions, acute
leukemia and the HOX signature
Mixed lineage leukemia (MLL) ... subsequent pro-
tein–protein interaction between the resulting MLL
fusion proteins. Thus, the MEN1 ⁄ LEDGF-interacting
domain linked to DNA-binding domains (AT-hook and
MT dom...
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... (Fig. 2A). The zinc ions are required
for the structural integrity of the protein, as mutation of
any of the cysteine residues involved in zinc coordina-
tion results in protein unfolding [22]. The ... CBP, CREB-binding protein; CREB, cAMP response element-binding;
H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL1, mixed lineage leukemia protein-1; PHD, plant...
Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt
... relying on routinely used lin-
ear fit of an arbitrarily chosen initial portion of each
kinetic trace. Applying linear regression of the reaction
progress could introduce a systematic error into ... model relied on determining the confidence
interval for the inhibition constant K
is
appearing in
Scheme 5. The 95% confidence intervals for inhibition
constants appearing in the mixed- ty...
Tài liệu Báo cáo khoa học: How to remain nonfolded and pliable: the linkers in modular a-amylases as a case study ppt
... participating
Table 1. Amino acid frequencies (%) in a-amylase linkers, in a set
of globular proteins, in the Swiss-Prot databank and in intrinsically
unstructured proteins.
Amino
acid Linkers
a
Globular
proteins
b
Swiss-Prot
c
Intrinsically
unstructured
proteins
b
Ala ... the ring may sterically disfavor extensive
bending in this region, which could result in unwanted
interacti...
Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf
... and of the
kanamycin insertion mutant nirF strain
(SBN03) in the upper right panel. Growth of
SBN11 (DnirF) is shown in the bottom left
panel and of SBN13 (DnirF) containing
pEG276-nirF in the ... similar-
ity with the C-terminal d
1
heme-containing domain of
cytochrome cd
1
. Strikingly, the axial ligand of iron in
d
1
heme in P. pantotrophus cd
1
(His200) is conserved i...
Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf
... furin into two fragments: the A chain
corresponding to the catalytic domain (C domain);
and the B chain corresponding to the translocation
domain (T domain) and the receptor-binding domain.
The ... 653
Introduction
Diphtheria toxin is a protein secreted by Corynebacte-
rium diphtheriae as a single polypeptide chain of
58 kDa [1]. During cell intoxication, diphtheria toxin
is cleaved by furi...
Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
... ‘con-
centration’ of glycosaminoglycans is best represented
in this situation by measuring the surface available to
enzyme binding, as reported in a study of cysteine pep-
tidases binding to insoluble elastin ... inhibitor interacts at two points with Arg217A, sug-
gesting a strategic role for this residue in the binding of
substrates and modifiers [14].
Reactivation of elastase-...
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