Tài liệu Báo cáo khoa học: DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling pptx

... genetics and epigenetics in Ras oncogenic signaling There is a bilateral relationship between genetic and epigenetic mechanisms in the activation of oncogenic Ras signaling. Activation of K -Ras and ... 5235 REVIEW ARTICLE DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling Insights from FAS, FAS ligand and RASSF1A Samir K. Patra 1, *...

Ngày tải lên: 18/02/2014, 14:20

... and HinfI for 3 h and recovered by ethanol precipitation. The precipitated DNA was dissolved in 3 lL of water and added into the ligation mixture [100 ng each of landmark- and HinfI-adapter and ... in other symbiotic and parasitic bacteria. These results suggest that DNA adenine methylation may contribute to the establishment and ⁄ or mainten- ance of symbiotic and parasit...

Ngày tải lên: 19/02/2014, 02:20

... DNA without any protein; lanes 2, 3 and 4 correspond to DNA complexes with p53(1–363), p73d and p73b, yielding retarded bands R 53 ,R 73d and R 73b , respectively. In lanes 5–7, the protein DNA ... one strand and two AG steps in the other. The mdm2 target, whose interaction with p53 was most strongly affected by DNA cis-platination, contains GG, GGG and AG motifs in one stran...

Ngày tải lên: 19/02/2014, 05:20

... of single-strand DNA (ssDNA) and assimilation of ssDNA into homologous super-coiled duplex DNA. J Biol Chem 276, 41906–41912. 10 Nara T, Hamada F, Namekawa S & Sakaguchi K (2001) Strand exchange ... single and double stranded DNA binding activity. Binding to single stranded DNA stimulated a significant level of DNA dependent ATPase activity. OsDmc1 also showed renaturation of...

Ngày tải lên: 19/02/2014, 07:20

... aromatic side chain. Modeling and molecular dynamics simulations In order to address the possible conformations and motions of the linkers, model building and molecular dynamics simulations were ... linker peptides and the engi- neering of size and composition variations in order to address their function in activity, substrate binding and structural dynamics. Materials and...

Ngày tải lên: 14/02/2014, 18:20

... S-transferase (GST)p, Ran 1 binding protein and C1q binding pro- tein], related to cell signaling, apoptosis and cytoskele- ton regulation (Fig. 2, insets; shaded versus white bars). On the other hand, ... 2010 The Authors Journal compilation ª 2010 FEBS 31 Andersen SS (2000) Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stath- min ⁄ Op18. Trends Cell...

Ngày tải lên: 15/02/2014, 01:20

... reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. Blood 112, 2869–2877. 151 Engels N, Wollscheid B & Wienands J (2001) Associa- tion ... transmembrane ligand EphrinB1) led to increased LAT phosphorylation and p44 ⁄ 42 and p38 MAPK activation [90]. This signalling pathway may be essential in T cell–T cell costimul...

Ngày tải lên: 18/02/2014, 04:20

... progression and tumour angio- genesis. Nat Rev Cancer 8, 632–645. 47 Klagsbrun M & Eichmann A (2005) A role for axon guidance receptors and ligands in blood vessel develop- ment and tumor angiogenesis. ... (e.g. hypoxia-inducible factor and Src-suppressed C kinase substrate ⁄ AKAP12) and soluble factors (e.g. vascular endothelial growth factor and angiopoie- tin-1), as well as...

Ngày tải lên: 18/02/2014, 11:20

... cells and astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO- proteins through a decrease in angiogenesis signaling and an ... embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep- tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1), Fig. 1. The VEGF–VEGFR system and the inhib...

Ngày tải lên: 18/02/2014, 11:20

... neurovascu- lar unit (Fig. 2). Loss of signaling between astrocytes and endothelium alters tight junction homeostasis and leads to BBB disruption. Perturbations in neuronal– glial signaling lead to loss of ... that angiogenesis may improve cerebral perfusion and func- tion as part of a network repair. The spatial and temporal dynamics of post-stroke angiogenesis are complex and...

Ngày tải lên: 18/02/2014, 11:20