Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... mechanism of rhodamine dyes, agents allowing the enhanced uptake of rhodamine dyes inhibited the efflux of these dyes from the cells. The efflux of rhodamine 123 and TMRM was inhib- ited by NBD-Cl and ... the multidrug resistance- associated protein (MRP1, ABCC1) [6] and breast cancer resistance protein (BCRP⁄ MXR ⁄ ABCP, Keywords innate multidrug resistance;...

Ngày tải lên: 18/02/2014, 13:20

... loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYK Alamdar Hussain 1,2, *, Liang Yu 1,3, *, Rani Faryal 1,2 , Dara K. Mohammad 1 , Abdalla J. Mohamed 1,4 and C. I. ... missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has been described previously in detail [...

Ngày tải lên: 14/02/2014, 18:20

... E22K, E22Q and D23N), and the availability of a rapid and simple expression and purification protocol will facilitate large-scale investigations of the molecular determinants of aggregation and fibrillation. ... supplied with the enzyme, and contained Aba, Abb and Abcat 40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of...

Ngày tải lên: 18/02/2014, 13:20

... additional binding of compound 6 at the IPP binding site, which is in the proximity of the allylic diphosphate binding site. Competition between IPP and allylic diphosphate for the IPP binding sites ... ninefold lower affinity of the enzyme for DMAPP vs. FPP (K m,DMAPP of 13.2 and K m,FPP of 1.5 l M [1]). The length of the hydrophobic carbon tail also affected the i...

Ngày tải lên: 21/02/2014, 00:20

... We adhere to the definition of opinion holders from previous work (Wiegand and Klakow, 2010; Wiegand and Klakow, 2011a; Wiegand and Klakow, 2011b), i.e. every source of a private state or a subjective speech ... Proceedings of the Annual Meeting of the Association for Computa- tional Linguistics (ACL), Sapporo, Japan. John Lafferty, Andrew McCallum, and Fernando Pereira. 2001....

Ngày tải lên: 22/02/2014, 02:20

... structure of MAP2 and the alignment of v-KIND -binding core (BD) region of MAP2 CD2 domain (702–744 aa) in human, mouse and Gallus This supplementary material can be found in the online version of this ... revealed the structural and func- tional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e. the MAP2 -binding core module in v-KIND and th...

Ngày tải lên: 14/02/2014, 19:20

... glycogen phosphorylase. II. Mode of binding of pyridoxal 5¢-phosphate and a nalogs of pyridoxal 5¢-phosphate to apophosphorylase b and the aggregation state of reconstituted phosphorylase proteins. ... timing of steps involved in dimer formation and a ppearance of thermostabilization by phosphate has been examined. The role of the cofactor 5¢-phosphate group in the induc...

Ngày tải lên: 19/02/2014, 16:20

... serotypes M1 (AP1 and 90–226), M5 and M6 (JRS4) were analysed for binding of 125 I-labelled DS. Isogenic mutants of AP1 (BM27.6, MC25, BMJ71), of 90–226 (90–226 emm1::Km), of M5 (DM5) and of JRS4 (JRS145), ... IgGFc -binding to the S-domain, and albumin -binding to the C-repeats [31]. Recombinantly expressed fragments rA–S and rS–C3 are indicated. (D) The M1 protein a...

Ngày tải lên: 20/02/2014, 11:20

... the area of the 11cROL and 13cROL peaks and expressed as the mean ± SD of three independent measurements. Retinal cell dissociation The zebrafish eyes were enucleated, and the corneas and lens were ... evolutionary analysis of DNA and protein sequences. Brief Bioinform 9, 299–306. 53 Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantitie...

Ngày tải lên: 14/02/2014, 14:20

... 917–924. 133 Fernandez Madrid F (2005) Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis. Cancer Lett 230, 187–198. a-enolase in tumor diagnosis and therapy ... therapeutic and diagnostic tumor target Michela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco Novelli Department of Medicine and Experimental Oncology, Center for Exp...

Ngày tải lên: 14/02/2014, 19:20