Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf

... furin into two fragments: the A chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and the receptor-binding domain. The ... of the pro- tein in the N state and the evolution of the overall structure of the protein in the MG state. This degree of resolution is unprecedented for...

Ngày tải lên: 16/02/2014, 09:20

... was observed in any of the EREs, irrespective of the absence and presence of E2. Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC 13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced ... and ERb was increased in both ERE1 and ERE2 in the presence of E2. Interestingly, the kinetics of E2-dependent binding of ERa and...

Ngày tải lên: 18/02/2014, 14:20

... (2009) 30 99 31 09 ª 2009 The Authors Journal compilation ª 2009 FEBS 31 09 Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa Egon Persson and Ole ... burial of the N-terminus of the protease domain increased similarly upon sTF binding to G372A-FVIIa and FVIIa. Thus Gly372(2 23) in FVIIa appears...

Ngày tải lên: 18/02/2014, 08:20

... catalyti- cally inactive. In this autoinhibited conformation, the SH2 domain binds to pY i on the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linker between the SH2 and kinase domains ... activating and inhibitory stimuli and more moderate changes in the amplitude of the oscillations. An increase in the acti- vating signal or decrease...

Ngày tải lên: 18/02/2014, 11:20

... together with amino acids in the neighboring c and d subunits (lying in loops D–F, the ‘secondary component’) that partici- pate in forming these binding pockets [7–9]. Although none of the ligand-gated ... expression. In uence of aR55F and aR55W mutant receptors on the binding of acetylcholine The binding properties of ACh were investigated in intact Xenopus oo...

Ngày tải lên: 19/02/2014, 07:20

... be explored further. Other areas of the brain have also been shown to regulate feeding via AMPK [35 ,36 ]. Of interest is the extensive use of fructose as a sweetener in the human diet [37 ]. Glucose and fructose are ... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript. Taken together, these findings provide a compelling argume...

Ngày tải lên: 14/02/2014, 22:20

... of pantoate bound in the ATP-binding pocket. Pantoate binding to the ATP-binding site induced large changes in structure, mainly for backbone and side chain atoms of residues in the ATP binding HXGH (34 37 ) ... binds to the GTP-binding site and inhibits the reaction [37 39 ]. The binding of pantoate to the ATP-binding site also reveals the origin of the ne...

Ngày tải lên: 16/02/2014, 09:20

... located at the level of the portal area, as expected in response to the protrusion of the glycine moieties, and at the level of strand F, strand H and strand I, in close contact with the ligand bound ... T 2 values in the apo protein and in all of the investigated holo proteins, thus plays a key role in regulating the positioning of the helix loop...

Ngày tải lên: 18/02/2014, 06:20

... for resistance to intracellular killing, the scavenging of free radicals and the reactivation of degenerated proteins during infection by a family of proteins named ‘thio- redoxins’ is one of the elegant ... protein–protein interaction rather than a DNA–protein interaction. To date, there has not been a single report to show that the WhiB pro- teins work as a DNA-binding pro...

Ngày tải lên: 18/02/2014, 12:20

... but the HNF-4-binding site is responsible for the SREBP-1 inhibition. SREBPs and HNF-4 physically interact through the N-terminal transactivation domain of SREBP and the C-terminal ligand-binding ... in that the nuclear import occurs in the absence of importin-a. Furthermore, the dimerization of SREBPs via the leucine zipper domain is required for the interac...

Ngày tải lên: 18/02/2014, 13:20