Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc
... known inhibitor of < /b> PI3 kinase activ-ity. In addition, the < /b> inhibition of < /b> mTOR activity wasachieved in the < /b> presence of < /b> 5 ngÆmL)1rapamycin, asrevealed by < /b> the < /b> absence of < /b> the < /b> phosphorylated form of< /b> p70S6K. ... activation by < /b> AKT elicits the < /b> phos-phorylation of < /b> two known regulators of < /b> protein syn-thesis, P70S6K and the < /b> eukaryotic initiation factor< /b> 4E-binding protein PHAS-1 (PHAS/4EBP1) [13, 14]< /b> ,thereby ... selective inhibitor of < /b> ganglioside biosynthesis,P4 [26], and characterized for their proliferation andA B CEDFig. 3. Neu2 expression < /b> is strictly depend-ent on insulin-like growth factor < /b> 1 (IGF-1)signaling....
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... the < /b> increasing expression < /b> of < /b> KLF4 in PBMC and THP-1 cells, andidentified that induction < /b> of < /b> KLF4 by < /b> HDL3promoted the < /b> expression < /b> of < /b> hSR-BI. It has been shown that dis-ruption of < /b> SR-BI in mice impairs ... that KLF4 is required for the< /b> expression < /b> of < /b> VSMC differentiation marker genesinduced by < /b> all-trans retinoic acid [4]< /b> ; KLF4 couldinduce inhibition of < /b> proliferation of < /b> VSMC, which ismechanistically ... successively. The < /b> immunoreactive bands were visualized using diamino-benzidine (DAB) (Boster Biological Technology, Wuhan,Hubei, China). The < /b> following antibodies were used: rabbitSRBI polyclonal antibody...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... suppressed by < /b> the < /b> Src-specific inhibitorCGP77675 as well as by < /b> the < /b> MEK1 inhibitor UO126and partially attenuated by < /b> the < /b> PI3K inhibitor Wort-mannin. No effect was observed with inhibitors of < /b> p38MAPK, ... phosphorylation andits association with Grb2 (Fig. 5B) . Interestingly, Srcinhibition also suppressed the < /b> disruption of < /b> cell–celladhesion, the < /b> scattered phenotype of < /b> the < /b> cells and the< /b> redistribution of < /b> ... suppressed by < /b> the< /b> inhibitor, suggesting that Src is located upstream of< /b> Shc in this signaling cascade (Fig. 5B) . Again, the< /b> Rho kinase inhibitor Y276 34 < /b> affected neither Decma-induced Erk activation...
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Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf
... that inNirS is the < /b> proximal axial ligand to the < /b> d1heme.Replacement of < /b> an equivalent His, His41, in NirF by< /b> Ala abolished binding of < /b> the < /b> heme to the < /b> protein.Known distal heme-binding residues, ... d1heme. It is concluded that His41 of < /b> NirF, which aligns with His200 of < /b> the < /b> d1heme domain of < /b> cd1, is essential both for this binding and for the< /b> production of < /b> d1heme; replacement of < /b> His41 by < /b> ... sequence)This workSBN21 DnirF derivative with pEG276-NirFH41KThis workSBN22 DnirF derivative with pEG276-NirFH41CThis workSBN23 DnirF derivative with pEG276-NirFH41MThis workSBN 24 < /b> DnirF derivative...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... Cu (I) 4< /b> Zn(II) 4< /b> -MT3 [32].Definitive studies will be important to explore the< /b> isostuctural replacement of < /b> Zn(II) with Cd(II), by< /b> monitoring the < /b> peptide structure and the < /b> flexibility of< /b> Zn(II) ... prop-erties similar to the < /b> isolated and the < /b> Cu (I) -reconsti-tuted Cu (I) 4< /b> Zn(II) 4< /b> MT3 described above, includingstability in air. The < /b> reaction of < /b> Zn(II)7MT3 withCu(II) has been proposed to be the < /b> ... stable in air in the < /b> presence of < /b> oneor two disulfide bonds. This could explain the < /b> sensitiv-ity to oxidation of < /b> freshly reconstituted Cu (I) 4< /b> ,Zn(II) 4< /b> MT3 and the < /b> stability of < /b> Cu (I) 4< /b> ,Zn(II) 4< /b> MT3...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... func-tion is the < /b> subject of < /b> detailed discussion in two otherminireviews in this series [26,27]. In this minireview wewill briefly describe the < /b> role of < /b> GIF in (a) regulation of< /b> metal ion homeostasis, ... insights into the < /b> functional roles of < /b> this protein in the < /b> brain, and in particular its abilityto inhibit neurite outgrowth (as described above). The < /b> functional role of < /b> GIF synthesis and secretionin ... forreducing neurodegeneration in the < /b> AD brain [39].It is important to note that while Ab aggregation canbe induced by < /b> both Cu(II) and Zn(II), only the < /b> Cu(II)-induced aggregation of < /b> Ab is toxic. The...
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Tài liệu Báo cáo khoa học: High-affinity ligand binding by wild-type/mutant heteromeric complexes of the mannose pptx
... binding IGF-II andpairing with a wild -type subunit does not repair the< /b> defect in the < /b> mutant site inducing it to bind IGF-II.This indicates that IGF-II binding to each side of < /b> the< /b> dimer is independent. ... assessedligand binding. Pairing of < /b> wild -type and point-mutated IGF-II binding sitesbetween two dimerized mini-receptors had no effect on the < /b> function of < /b> the< /b> contralateral binding site, indicating IGF-II ... online publication: in Fig. 4D ‘IP:a-FLAG’ was corrected to ‘IP: a-Myc’, and in Fig. 4F ‘125 I- PMP-BSAbinding’ was corrected to ‘125 I- IGF-II binding’.]Ligand binding by < /b> the < /b> dimeric M6P ⁄ IGF2R...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... G(1991) The < /b> purification of < /b> tissue inhibitor of < /b> metallo-proteinases-2 from its 72 kDa progelatinase complex.Demonstration of < /b> the < /b> biochemical similarities of < /b> tissueinhibitor of < /b> metalloproteinases-2 ... [8].Another MMP inhibitor, reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a cell mem-brane associated inhibitor of < /b> MMP-2 that is able toinhibit the < /b> second activation step of < /b> ... viability indepen-dent of < /b> MMPs [44< /b> ,45< /b> ]. One of < /b> the < /b> aims of < /b> currentresearch on MMPs and TIMPs in cancer is to establish the < /b> localization and timeframe for their expression,< /b> aswell as the < /b> identification...
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
... to the < /b> untreated p2 1b. The < /b> behavior of < /b> the < /b> PGM4 site was similar to that of< /b> p2 1b, showing practically no inhibition of < /b> p53–PGM4binding for r b ¼ 0.02 or 0. 04 < /b> and about 10% inhibi-tion for r b ¼ ... and the < /b> ability of < /b> the < /b> particular p53target site to accommodate the < /b> cisplatin IACs. The< /b> higher the < /b> probability of < /b> formation of < /b> the < /b> cisplatinIACs within the < /b> p53DBSs due to the < /b> occurrence of< /b> the < /b> ... modification with the < /b> antitumor drug cisplatin inhibitsp53 binding to a synthetic p53 DNA-binding site. Here we demonstratethat the < /b> effects of < /b> global DNA modification with cisplatin on binding of< /b> the...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... by < /b> these ions [41< /b> ] which would not be beneficial in the< /b> light of < /b> higher toxicity of < /b> such aggregates [3]. The < /b> discovery that copper binding to stefin B inhib-its fibril formation but does ... stud-ies of < /b> the < /b> P79S mutant, which differs from the < /b> copperbinding forms of < /b> stefin B by < /b> one amino acid residueFig. 7. Inhibition of < /b> amyloid fibril growth as observed by < /b> TEM. Samples at 34 < /b> lM protein ... describedfor other amyloidogenic proteins, including amyloid -b peptide [7]. By < /b> following the < /b> kinetics of < /b> stefin B fibrilformation, conditions were defined where the < /b> proteinexists in the < /b> form of...
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