Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx

... known inhibitor of < /b> PI3 kinase activ- ity. In addition, the < /b> inhibition of < /b> mTOR activity was achieved in the < /b> presence of < /b> 5 ngÆmL )1 rapamycin, as revealed by < /b> the < /b> absence of < /b> the < /b> phosphorylated form of < /b> p70S6K. ... activation by < /b> AKT elicits the < /b> phos- phorylation of < /b> two known regulators of < /b> protein syn-...

Ngày tải lên: 19/02/2014, 06:20

... the < /b> increasing expression < /b> of < /b> KLF4 in PBMC and THP-1 cells, and identified that induction < /b> of < /b> KLF4 by < /b> HDL 3 promoted the < /b> expression < /b> of < /b> hSR-BI. It has been shown that dis- ruption of < /b> SR-BI in mice impairs ... that KLF4 is required for the < /b> expression < /b> of < /b> VSMC differentiation marker genes induced by < /b> a...

Ngày tải lên: 18/02/2014, 04:20

... suppressed by < /b> the < /b> Src-specific inhibitor CGP77675 as well as by < /b> the < /b> MEK1 inhibitor UO126 and partially attenuated by < /b> the < /b> PI3K inhibitor Wort- mannin. No effect was observed with inhibitors of < /b> p38 MAPK, ... phosphorylation and its association with Grb2 (Fig. 5B) . Interestingly, Src inhibition also suppressed the < /b> disruption of < /b> cell–...

Ngày tải lên: 19/02/2014, 05:20

... that in NirS is the < /b> proximal axial ligand to the < /b> d 1 heme. Replacement of < /b> an equivalent His, His41, in NirF by < /b> Ala abolished binding of < /b> the < /b> heme to the < /b> protein. Known distal heme-binding residues, ... d 1 heme. It is concluded that His41 of < /b> NirF, which aligns with His200 of < /b> the < /b> d 1 heme domain of < /b> cd 1 , is essential...

Ngày tải lên: 15/02/2014, 01:20

... Cu (I) 4 < /b> Zn(II) 4 < /b> -MT3 [32]. Definitive studies will be important to explore the < /b> isostuctural replacement of < /b> Zn(II) with Cd(II), by < /b> monitoring the < /b> peptide structure and the < /b> flexibility of < /b> Zn(II) ... prop- erties similar to the < /b> isolated and the < /b> Cu (I) -reconsti- tuted Cu (I) 4 < /b> Zn(II) 4 < /b> MT3 described above, in...

Ngày tải lên: 16/02/2014, 15:20

... func- tion is the < /b> subject of < /b> detailed discussion in two other minireviews in this series [26,27]. In this minireview we will briefly describe the < /b> role of < /b> GIF in (a) regulation of < /b> metal ion homeostasis, ... insights into the < /b> functional roles of < /b> this protein in the < /b> brain, and in particular its ability to inhibit neurite outgrowth (as descr...

Ngày tải lên: 16/02/2014, 15:20

... binding IGF-II and pairing with a wild -type subunit does not repair the < /b> defect in the < /b> mutant site inducing it to bind IGF-II. This indicates that IGF-II binding to each side of < /b> the < /b> dimer is independent. ... assessed ligand binding. Pairing of < /b> wild -type and point-mutated IGF-II binding sites between two dimerized mini-receptors had no effect on the < /b>...

Ngày tải lên: 18/02/2014, 08:20

... G (1991) The < /b> purification of < /b> tissue inhibitor of < /b> metallo- proteinases-2 from its 72 kDa progelatinase complex. Demonstration of < /b> the < /b> biochemical similarities of < /b> tissue inhibitor of < /b> metalloproteinases-2 ... [8]. Another MMP inhibitor, reversion-inducing cysteine- rich protein with kazal motifs (RECK) is a cell mem- brane associated inhibitor of <...

Ngày tải lên: 18/02/2014, 11:20

... to the < /b> untreated p2 1b. The < /b> behavior of < /b> the < /b> PGM4 site was similar to that of < /b> p2 1b, showing practically no inhibition of < /b> p53–PGM4 binding for r b ¼ 0.02 or 0. 04 < /b> and about 10% inhibi- tion for r b ¼ ... and the < /b> ability of < /b> the < /b> particular p53 target site to accommodate the < /b> cisplatin IACs. The < /b> higher the <...

Ngày tải lên: 19/02/2014, 05:20

... by < /b> these ions [41< /b> ] which would not be beneficial in the < /b> light of < /b> higher toxicity of < /b> such aggregates [3]. The < /b> discovery that copper binding to stefin B inhib- its fibril formation but does ... stud- ies of < /b> the < /b> P79S mutant, which differs from the < /b> copper binding forms of < /b> stefin B by < /b> one amino acid residue Fig. 7. Inhib...

Ngày tải lên: 19/02/2014, 06:20