Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... (2010) 366 4–3 674 ª 2010 The Authors Journal compilation ª 2010 FEBS REVIEW ARTICLE Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control Filipa ... profiles and in their distribution in the central nervous system and periphery. Y1 , Y2 and Y5 are the best characterized NPY receptors,...

Ngày tải lên: 18/02/2014, 04:20

... potency was pPYY > pNPY > cPYY > cPP (see Table 1). Interestingly, pNPY had a lower affinity than pPYY, thereby making it unlikely that cNPY would bind with higher affinity (they differ by ... NPY (cNPY)-family receptors, namely Y 1 ,Y 2 ,Y 4 and Y 5 [2 7–2 9]. The genes for Y 1 ,Y 2 and Y 5 are clustered together on Homo sapiens chromosome 4 (Hsa4), the Y 4 g...

Ngày tải lên: 19/02/2014, 07:20

... generate standard curves by plot- ting the initial template amount on the x-axis and the thresh- old cycle (C t ) on the y- axis. The PCR efficiency is given by 10 ()1 ⁄ slope) ) 1, where the slope ... that they detect. Primers detected the serotypes they were predicted to detect; there were no false negatives for any of the primer groups. Specificity for dengue is expected t...

Ngày tải lên: 14/02/2014, 19:20

... Although the proteins involved in such diseases do not have any similarity in their pri- mary sequence and ⁄ or structure, the aggregates formed do exhibit similarity in their topology. They exhibit crossed ... of a-synuclein after 240 h. Samples containing MPTP (A and C) and MPP + (B and D) were analysed by SDS ⁄ PAGE (A and B) on 5–1 5% crosslinked polyacrylamide gel and w...

Ngày tải lên: 14/02/2014, 19:20

... by its ability to substitute for P i in the F 0 F 1 -ATP synthase catalyzed reaction of phosphorylation of ADP. How- ever, the AsO 3 -ADP bond is easily and non-enzymati- cally water-hydrolysable, ... of the model with experimental evidence on the relevant conditions, we measured the flux control coefficients (FCCs) of the reactions catalyzed by the ANT and the F 0 F 1 -AT...

Ngày tải lên: 14/02/2014, 19:20

... transiently transfected with DAT and p25a, a-syn or the empty vector as a negative control. The x axis shows the total concentration of DA and the y axis shows the DA uptake after 10 min. The y axis ... shown on the left, and the antigens are indicated on the right. (B) Localization of DAT and p25a transiently expressed in SH-SY 5Y cells was ana- lyzed by confo...

Ngày tải lên: 14/02/2014, 21:20

... enzymeÆreactivase complexes by nondenaturing PAGE When the enzymeÆCN-Cbl complex was incubated with the reactivase in the presence of ADP and Mg 2+ and followed by nondenaturing PAGE, the bands of the enzyme and the ... indicated on the tops of chromatograms. A B C 66 K– 66 K– 45 K– 36 K– 29 K– 24 K– 20 K– 14 K– Fig. 5. Analysis of the enzymeÆreactivase complex by PAGE....

Ngày tải lên: 15/02/2014, 01:20

... malignant phenotype. The most Fig. 2. EGFR and ERBB proteins and their downstream pathways. T. Mitsudomi and Y. Yatabe EGFR and cancer FEBS Journal 277 (2010) 30 1–3 08 ª 2009 The Authors Journal ... relatively low, being 33, 24 and 28%, respectively. Structure of the ERBB proteins and diversity of their ligands The EGFR gene is located on chromosome 7p12-13 and codes...

Ngày tải lên: 16/02/2014, 09:20

... in green and the colors for the CBP–KIX:cMyb are as in (B). Upon formation of the ternary complex, residues E665 and E666 of the CBP–KIX domain become ordered and interact with the c-Myb transactivation ... MLL1 and other metazoan SET1 family members functions to bind the WDR5 compo- nent of the WDR5–RbBP5–Ash2L sub-complex, which is required for the assembly and H3K...

Ngày tải lên: 16/02/2014, 14:20

... that the GIF protein is primarily synthesized in astrocytes, where it is found predominantly in the soma and fine processes of these cells. Astrocytic synthesis of GIF is mainly found in the cortex, ... brain injury (Fig. 1). As neurons degenerate, the surrounding astrocytes respond by proliferating and assume a reac- tive phenotype. GIF synthesized by reactive astrocytes may be se...

Ngày tải lên: 16/02/2014, 15:20