Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt
Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt
... (2010) 366 4–3 674 ª 2010 The Authors Journal compilation ª 2010 FEBSREVIEW ARTICLE Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control Filipa ... profiles and in their distributionin the central nervous system and periphery. Y1 , Y2 and Y5 are the best characterized NPY receptors, and the majority of NPY functions are associated withthem. ... cells and osteoblasts [40,4 6–4 8],despite the absence of the other Y receptors (Y2 , Y4 , Y5 and y6 ) [40,46]. In addition to the presence ofNPY-immunoreactive fibers and the presence ofNPY receptors,...
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Tài liệu Báo cáo khoa học: Neuropeptide Y-family receptors Y6and Y7in chicken Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region docx
... potency was pPYY > pNPY >cPYY > cPP (see Table 1). Interestingly, pNPY had alower affinity than pPYY, thereby making it unlikelythat cNPY would bind with higher affinity (they differby ... NPY (cNPY)-familyreceptors, namely Y 1 ,Y 2 ,Y 4 and Y 5[2 7–2 9]. The genes for Y 1 ,Y 2 and Y 5are clustered togetheron Homo sapiens chromosome 4 (Hsa4), the Y 4gene islocated on Hsa10 and ... retain any duplicates of Y 5, and in the Y 2subfamily only Y 2 and Y 7are known. In the Y 1subfamily, in contrast, a full quartet probablyexisted after the tetraploidizations with Y 1 ,Y 4(previ-ously...
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Tài liệu Báo cáo khoa học: PCR detection of nearly any dengue virus strain using a highly sensitive primer ‘cocktail’ ppt
... generate standard curves by plot-ting the initial template amount on the x-axis and the thresh-old cycle (Ct) on the y- axis. The PCR efficiency is given by10()1 ⁄ slope)) 1, where the slope ... that they detect.Primers detected the serotypes they were predicted todetect; there were no false negatives for any of the primer groups. Specificity for dengue is expected to bevery good; the ... specifically by the primer pair 1G5P30 with perfectprimer match. The genotype classification of each strain was determinedeither by referring to the published literature [2 8–3 4] or byusing the Dengue...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... Although the proteins involved insuch diseases do not have any similarity in their pri-mary sequence and ⁄ or structure, the aggregates formeddo exhibit similarity in their topology. They exhibitcrossed ... of a-synuclein after 240 h. Samples containingMPTP (A and C) and MPP+(B and D) were analysed by SDS ⁄ PAGE(A and B) on 5–1 5% crosslinked polyacrylamide gel and westernblotting (C and D). ... incubated alone, and in the presence of100 lm MPTP and 200 lm MPTP, respectively. Nota-bly, in the presence of the neurotoxin, there was adelay in the lag time for fibrillation. The lag timeincreased...
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Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... by itsability to substitute for Piin the F0F1-ATP synthasecatalyzed reaction of phosphorylation of ADP. How-ever, the AsO3-ADP bond is easily and non-enzymati-cally water-hydrolysable, ... of the model withexperimental evidence on the relevant conditions, wemeasured the flux control coefficients (FCCs) of the reactions catalyzed by the ANT and the F0F1-ATPsynthase separately ... before and after the addition of ADP(2 mm) to WT and CYPD KO mitochondria, and cal-culated on the basis of steady-state titration data bycatr and olgm. The activities of ANT and F0F1-ATPsynthase...
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx
... transiently transfected with DAT and p25a, a-syn or the empty vector as a negative control. The x axis shows the total concentration of DA and the y axis shows the DA uptake after 10 min. The y axis ... shown on the left, and the antigens are indicated on the right. (B) Localizationof DAT and p25a transiently expressed in SH-SY 5Y cells was ana-lyzed by confocal laser scanning microscopy. A representative ... of the a-syn-mediated effect on DA uptake, abnormalfunction or aggregation of a-syn in dopaminergic neu-rons may affect the DA balance, and thereby increaseoxidative stress in the cell.The...
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Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf
... enzymeÆreactivasecomplexes by nondenaturing PAGEWhen the enzymeÆCN-Cbl complex was incubated with the reactivase in the presence of ADP and Mg2+ and followed by nondenaturing PAGE, the bands of the enzyme and the ... indicated on the tops of chromatograms.ABC66 K–66 K–45 K–36 K–29 K–24 K–20 K–14 K–Fig. 5. Analysis of the enzymeÆreactivase complex by PAGE. Exper-imental details are described in the text. ... released from the enzyme by the reactivase. One reason might be itslarger size, and the other possible reason might be that the additional interaction between its adenine moiety and the enzymes’s adenine-binding...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... malignant phenotype. The mostFig. 2. EGFR and ERBB proteins and their downstream pathways.T. Mitsudomi and Y. Yatabe EGFR and cancerFEBS Journal 277 (2010) 30 1–3 08 ª 2009 The Authors Journal ... relatively low, being 33, 24 and 28%, respectively.Structure of the ERBB proteins and diversity of their ligands The EGFR gene is located on chromosome 7p12-13 and codes for a 170kDa receptor tyrosine ... to ERBB3 and ERBB4.NRG1 and NRG2 bind to both ERBB3 and ERBB4,whereas NRG3 and NRG4 only bind to ERBB4 [3].Although these ligands show redundancy, heparin-binding-EGF is the only ligand whose...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... in green and the colors for the CBP–KIX:cMyb are as in (B). Upon formation of the ternary complex, residues E665 and E666 of the CBP–KIX domain become ordered and interact with the c-Myb transactivation ... MLL1 and other metazoan SET1family members functions to bind the WDR5 compo-nent of the WDR5–RbBP5–Ash2L sub-complex, whichis required for the assembly and H3K4 dimethylationactivity of the ... representation of the MLL1 SET domain (grey)shown with a symmetry related molecule in red. The N-terminus of the symmetry related molecule interacts extensively with the SET-Iregion – constraining the MLL1...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... that the GIF protein is primarily synthesized in astrocytes,where it is found predominantly in the soma and fineprocesses of these cells. Astrocytic synthesis of GIFis mainly found in the cortex, ... braininjury (Fig. 1). As neurons degenerate, the surroundingastrocytes respond by proliferating and assume a reac-tive phenotype. GIF synthesized by reactive astrocytesmay be secreted by these ... retaining all the 20 conserved cysteine residues[2]. The only structural differences between GIF and MT1 and MT2 include a Cys-Pro-Cys-Pro( 6–9 ) motif and Thr5 in the b-domain of GIF and a differentamino...
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