... stability.AbbreviationsALLN, N-acetyl-L-leucyl-L-leucyl-L-norleucinal; GAP, GTPase activating protein; G protein, heterotrimeric guanine nucleotide-binding protein;GPCR, G protein-coupled receptor; GRK, G protein-coupled ... RGS domain in the amino-terminus of Gprotein-coupled receptor kinase 2 inhibits Gq-mediatedsignaling. Int J Mol Med 5, 335–340.20 Chen CA & Manning DR (2001) Regulation of G pro-teins by ... degradation of the phosphoinositidaseC-linked guanine-nucleotide-binding protein Gqalpha ⁄ G11 alpha following activation of the human M1muscarinic acetylcholine receptor expressed in CHOcells....