Tài liệu Báo cáo khoa học: Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis doc

... pooled human IgG to a pH 4 buffer resulted in an increase in its pre-existing binding to antigens present in an Escherichia coli lysate, and in the appearance of some new bands showing the acquisition of ... compilation ª 2010 FEBS Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activi...

Ngày tải lên: 16/02/2014, 15:20

... lipids of the lower leaflet to pack more tightly and extend their acyl chains to maintain the integrity of the membrane. The substantial tilt (and resulting disorder) of the top leaf- let lipids and ... ‘tiers’ at increasing distance from Ab40. The first and second tiers contained 20 lipids each, and the third tier con- tained the remaining lipids in the leaflet, between 18...

Ngày tải lên: 18/02/2014, 08:20

... identical paths in MT and ASR word graphs are increased to 39.7% and 34.4% of the sentences in development and evaluation sets, respectively. The WER of the integrated system are 19.0% and 20.7% for ... the results are not promising compared to the results of the rescoring method presented in Table 2 for HMM and IBM translation models. A detailed analysis reveale...

Ngày tải lên: 20/02/2014, 12:20

... use- ful for studies of ligand–receptor interactions and 3D modeling, and we have previously been able to utilize differences between chicken and human Y 2 in antagon- ist binding for this purpose ... peptides are involved in a variety of neuronal and endocrine functions, including regula- tion of appetite and circadian rhythm, as well as cardiovascular, reproductive an...

Ngày tải lên: 19/02/2014, 07:20

... single line scan data obtained with buffer conditions. (A) Representative single line scan graphs obtained at increasing ATP concentration in the range 0–100 l M and in the presence of 10 nM and ... were obtained in the presence of 100 l M free Ca 2+ and in the presence of 10 nM (B) and 1 lM ATP (C), respectively [scanning rate of 250 Hz, scan scale of 208 nm (y-axis...

Ngày tải lên: 14/02/2014, 14:20

... the administration of proinflammatory cytokines, leading to a loss of catalytic activity. This downregulation was at the level of transcription [26]. In the present study, the activity and protein and ... lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, we employed GdCl 3 to inactivate KCs ba...

Ngày tải lên: 14/02/2014, 18:20

... physicochemical and structural studies, cellular and animal models, and clinical studies. In addition to providing a basic understanding of the pro- cesses of protein folding and aggregation, ... principle of domain-swap- ping and how this can underlie the process of amyloid- fibril formation. Cystatins and stefins: an example of domain-swapping proteins forming amyl...

Ngày tải lên: 14/02/2014, 18:20

... line), in the presence of 100 l M neurotoxin ( • , dotted line), in the presence of 200 l M neurotoxin ( , dotted line) and in the presence of neurotoxin and 50 l M dopamine (h, dashed line). Modulation ... a-synuclein (control); lane 2, with 100 l M neurotoxin; lane 3, with 200 lM neu- rotoxin; lane 4, with 100 l M neurotoxin and 50 lM dopamine; lane 5, with 200 l M neuroto...

Ngày tải lên: 14/02/2014, 19:20

... the inner membrane by means of the decreasing matrix P i con- centration, which in turn could affect CYPD binding to F 0 F 1 -ATP synthase, and decreased binding of the inhibitory protein IF 1 to ... to an insignificant increase (1.38–1.7%) in the ADP–ATP exchange rate mediated by the ANT in maximally polarized (forward mode of both ANT and ATPase) and maximally depol...

Ngày tải lên: 14/02/2014, 19:20

... junctions (6). Injected CagA and peptidoglycan (5), in addition to OipA (1), can trigger NF-jB activation (7) and the release of pro -in ammatory cytokines such as IL-8 (8). These cytokines can alter ... the amount of intracellu- lar CagA PY . Cortactin, ezrin and vinculin are all Src substrates, and Src inactivation causes dephosphoryla- tion of these proteins and is cruc...

Ngày tải lên: 14/02/2014, 19:20