Tài liệu Báo cáo khoa học: Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection ppt
Tài liệu Báo cáo khoa học: Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection ppt
... FEBS 1283 Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection Sandra ... and VP3 are potent inducers of apoptosis We further examined the character of cell death induced by VP2 or VP3 proteins. To assess the con-tribution of apoptosis to toxicity, we evaluated the cleavage ... capsid pro-teins are not the sole or even the main inducers of apoptosis in the infection process and are dispensablefor cell death. During infection, most of the minor capsid proteins become...
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Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx
... proteincomponents are integral in the membrane, most of these mitochondrial pro-teins behave as if they have a-helical transmembrane domains, rather thanb-barrels. These proteins are usually predicted to ... previouslyand shown in Fig. 1C, Tom20 and Tom22 migrateclosely together on this gel system [30]. Tom70 andTom71 also migrate closely together on the gel, and the relative intensity of Coomassie staining ... the N-terminalstretch of Om14, the three transmembrane segmentmodel of Om14 is the only one consistent with our data.Om14 is not a subunit of the TOM, SAM ormorphology-related complexesProteins...
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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
... bud-ding of the immature virion. The viral protease-medi-ated processing of Gag into several independent proteins and peptides leads to the disassembly of the spherical capsid inside the virion. ... immatureHIV-1 capsid, or in the reassembly of CA into amature capsid. The detailed description of the structureand conformational dynamics of these interfaces,together with a quantitative dissection of ... superposition on the elec-tron density maps of the atomic structure of eachdomain. The Gag subunits are radially extended, with the N-terminal domain, MA, associated with the innerlayer of the viral...
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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly ppt
... assembly of the mature HIV-1 capsid in vitro. However, because of the lack of permeability of cells to CAI, the peptide wasunable to inhibit HIV-1 infection ex vivo. The CAIpeptide isolated in ... the conformations of the two assembly-incompetentmutants (Y169A and L211A) in the absence of CAI are the same as the structures of any mutant when complexed to the peptide. Interestingly, Glu187(together ... shifts of the whole dimer-ization helix of CTD [27] (otherwise, those chemicalshifts are too broad to be observed because of the presence of interconverting conformers) [29]. The bind-ing site of...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... that conephotoreceptors recovered light sensitivity followingphotobleaching when the cone photoreceptors are con-nected with other retinal cells, but not with the RPE;rod photoreceptors did not ... ganglion cells might contribute to providing chromophore to melanopsin to maintaintheir light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to beinvestigated.Earlier ... thetase to esterify the 13cROL generated in the reac-tion. Therefore, 13cROL is accumulated in the absence of LRAT in the reaction (Fig. S3B).Under the in vitro assay conditions of the...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... analysis. The activation of CD4+cells, however, dramaticallyinduces transcription of the ITK gene and is key for the productive infection of HIV in these cells. Accord-ingly, the inhibition of ITK ... versions of the fusion proteins were not readily phosphorylated in either cell type.In particular, the phosphorylation, but also the totalprotein level, of BTK–SYK was less than that of ITK–SYK ... in the BTK gene are missenseand some of these reduce the stability of the protein.This is exemplified by mutations in the BTK motif of the Tec homology (TH) domain [18]. This region isknown to...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... and needs to beexplored further. Other areas of the brain have alsobeen shown to regulate feeding via AMPK [35,36]. Of interest is the extensive use of fructose as asweetener in the human ... catabo-lism is the translocation of long-chain fatty acyl-CoAsfrom the cytoplasm, where they are made de novo orimported from the extracellular space, to the mito-chondrial matrix where the oxidative ... become apparent that certain regions of the brain, notably the hypothalamus, are also respon-sive to circulating nutrients that reflect the energy sta-tus of the animal. These nutrients too can...
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx
... advance of clinicalapplications, further studies are necessary to define the transcriptional regulatory mechanisms regulating thesefactors, identify their cognate receptors and character-ize their ... maintain the vascular system and hemato-poietic stem cells through the Tie2 receptor [6]. How-ever, ANGPTLs do not bind to either Tie2 or the related protein Tie1, suggesting that these orphanligands ... tissue,although they are not obese [15]. The expression of inflammatory cytokines (tumor necrosis factor-a, inter-leukin-6 and interleukin-1b) was increased in the adi-pose tissue of ANGPTL2 transgenic...
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Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... receptor-mediated apoptosis in many cell systems [16,17]. The BH3domain -only proteins are a subfamily of the Bcl-2family involved in the initiation of apoptosis through the mitochondrial pathway. The key ... andresistance to apoptosis through downregulation of tBid, providing furtherdetails on how EGF receptor and proteasome inhibitors can contribute to the induction of apoptosis and the treatment of cancer.Structural ... in the mito-chondrial pathway is the release of proapoptotic fac-tors from the mitochondrial intermembrane space into the cytosol, resulting in the downstream activation of afamily of cytosolic...
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Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... measures the total dye amount associatedwith the cells, including the dye adsorbed to the sur-face of the cells. To avoid complication of the uptake studies byactive pumping of the dyes into the ... FEBSup into the cells was less than the amount adsorbed to the cell surface. The amounts of the other rhodaminedyes were somewhat higher, but still < 3.5 times the amounts adsorbed to the cell ... constant, k. The amount of dye associated with the cells is expressed as the apparent cell volume of dye bound to a cell, which is equivalent to the concentration ratio of dye bound to the cellsversus...
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