Tài liệu Báo cáo khoa học: Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection ppt

... FEBS 1283 Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection Sandra ... and VP3 are potent inducers of apoptosis We further examined the character of cell death induced by VP2 or VP3 pro...

Ngày tải lên: 16/02/2014, 09:20

... protein components are integral in the membrane, most of these mitochondrial pro- teins behave as if they have a-helical transmembrane domains, rather than b-barrels. These proteins are usually predicted to ... previously and shown in Fig. 1C, Tom20 and Tom22 migrate closely together on this gel system [30]. Tom70 and Tom71 also migrate closely together on the gel, and the rel...

Ngày tải lên: 19/02/2014, 07:20

... bud- ding of the immature virion. The viral protease-medi- ated processing of Gag into several independent proteins and peptides leads to the disassembly of the spherical capsid inside the virion. ... immature HIV-1 capsid, or in the reassembly of CA into a mature capsid. The detailed description of the structure and conformational dynamics of these inter...

Ngày tải lên: 18/02/2014, 06:20

... assembly of the mature HIV-1 capsid in vitro. However, because of the lack of permeability of cells to CAI, the peptide was unable to inhibit HIV-1 infection ex vivo. The CAI peptide isolated in ... the conformations of the two assembly-incompetent mutants (Y169A and L211A) in the absence of CAI are the same as the structures of any mutant when comp...

Ngày tải lên: 18/02/2014, 06:20

... that cone photoreceptors recovered light sensitivity following photobleaching when the cone photoreceptors are con- nected with other retinal cells, but not with the RPE; rod photoreceptors did not ... ganglion cells might contribute to providing chromophore to melanopsin to maintain their light sensitivities. The expression and function of RPE65c in other cell types in...

Ngày tải lên: 14/02/2014, 14:20

... analysis. The activation of CD4 + cells, however, dramatically induces transcription of the ITK gene and is key for the productive infection of HIV in these cells. Accord- ingly, the inhibition of ITK ... versions of the fusion proteins were not readily phosphorylated in either cell type. In particular, the phosphorylation, but also the total protein level, of...

Ngày tải lên: 14/02/2014, 18:20

... and needs to be explored further. Other areas of the brain have also been shown to regulate feeding via AMPK [35,36]. Of interest is the extensive use of fructose as a sweetener in the human ... catabo- lism is the translocation of long-chain fatty acyl-CoAs from the cytoplasm, where they are made de novo or imported from the extracellular space, to the mito- cho...

Ngày tải lên: 14/02/2014, 22:20

... advance of clinical applications, further studies are necessary to define the transcriptional regulatory mechanisms regulating these factors, identify their cognate receptors and character- ize their ... maintain the vascular system and hemato- poietic stem cells through the Tie2 receptor [6]. How- ever, ANGPTLs do not bind to either Tie2 or the related protein Tie1, suggesting...

Ngày tải lên: 14/02/2014, 22:20

... receptor-mediated apoptosis in many cell systems [16,17]. The BH3 domain -only proteins are a subfamily of the Bcl-2 family involved in the initiation of apoptosis through the mitochondrial pathway. The key ... and resistance to apoptosis through downregulation of tBid, providing further details on how EGF receptor and proteasome inhibitors can contribute to...

Ngày tải lên: 16/02/2014, 09:20

... measures the total dye amount associated with the cells, including the dye adsorbed to the sur- face of the cells. To avoid complication of the uptake studies by active pumping of the dyes into the ... FEBS up into the cells was less than the amount adsorbed to the cell surface. The amounts of the other rhodamine dyes were somewhat higher, but still...

Ngày tải lên: 18/02/2014, 13:20