Tài liệu Báo cáo khoa học: RMI1 deficiency in mice protects from diet and genetic-induced obesity pptx

... in RMI1 + ⁄ ) mice (Table 1). Resistance to diet- induced obesity in RMI1+ /) mice Wild-type (RMI1+ ⁄ +) and heterozygous (RMI1+ ⁄ )) littermate mice were created via in vitro fertilization using ... tolerance test showed that diet- induced glucose intolerance improved significantly in RMI1+ ⁄ ) mice (Fig. 2C,D). Insulin levels did not differ between RMI1+ ⁄ + and...

Ngày tải lên: 16/02/2014, 09:20

... acid buffer for 15 min and then preincubated in detecting buffer (0.1 m Tris ⁄ HCl, 0.1 m NaCl, pH 9.5) for 5 min. Finally, membranes were incubated in detecting buffer containing CDP-star sub- strate ... ‘New’ functions for ‘old’ proteins: The role of the calcium- binding proteins calbindin D-28k, calretinin and parval- bumin, in cerebellar physiology. Studies with knockout mice....

Ngày tải lên: 19/02/2014, 07:20

... Pragmatic Issues in the Planning of Definite and Indefinite Noun Phrases Douglas E. Appelt Artificial Intelligence Center, SRI International and Center for the Study of Language and Information ... Stanford University 1 Introduction In this paper we examine the pragmatic knowledge an utterance-planning system must have in order to produce certain kinds of definite and in...

Ngày tải lên: 21/02/2014, 20:20

... of including blanks be- tween words. Figure 1 shows an example of the morpheme extraction process for Japanese text. Because of the disadvantage inherent in reading difficulty involved in ... the input character. Because morphemes are arranged in the incremental order of their key string in the dictionary, the pair for the top address and the number expresses the address ran...

Ngày tải lên: 21/02/2014, 20:20

... bd phan cdng chiing va ngay ehinh bd phan cdng chiing ay cung khdng d'n dinh. Dii sao di niia thi edng ehiing ciing dang quyet dinh hay gdp phan quyet dinh sir thanh edng ... tam chia edng ehiing thanh hai loai edng chiing nghe thuat: edng chiing tinh hoa va cdng chiing phd' thdng. Cdng chiing tinh hoa la nhiing ngudi am hie'u nghe thuat, hp dugc...

Ngày tải lên: 18/02/2014, 03:20

... upon ligand binding. Indeed, high T 1 ⁄ T 2 ratios were observed for Tyr9 and Gln11 (strand A), Arg32 (helix II), Val90, Lys92, and Glu94 (strand G), Phe96 and Ser97 (strand H), Phe113 (strand I), and ... lead to distinct binding and functional properties [22,23]. In line with this, we have shown here that the presence of a disulfide bridge, while maintaining the same binding stoic...

Ngày tải lên: 18/02/2014, 06:20

... RPE65c and GS staining (B3), and 4¢,6-diamidino-2-phenylindole (DAPI) staining (B4), respectively. (B5-8) High magnification images of the boxed area in (B4) showing RPE65c staining (B5), GS staining ... con- taining atRE (A), liposomes containing atRE in the presence of 1m M bipyridine (B) and liposomes containing atRE, in the presence of 1 m M bipyridine and 6 mM FeSO 4 (C). Th...

Ngày tải lên: 14/02/2014, 14:20

... directly involved in ligand binding, presumably abolishing the interaction with signaling partners. The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce ... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry- ing a fusion protein, originating from a translocat...

Ngày tải lên: 14/02/2014, 18:20

... v-KIND binding core). Input (cerebellum) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND Input (MAP2) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND PD from cerebellar lysates PD from ... stain) EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 KIND2-1 487 KIND2-2 521 KIND2-3 555 KIND2-5 589 KIND2-4 488 456 620 KIND2 v-KIND + + + – –...

Ngày tải lên: 14/02/2014, 19:20

... cytochrome c from mitochon- dria into the cytosol through inactivation with Bcl-xL and Bcl-2 [69]. Inactivated Bax and Bad bind 14-3-3, the phosphoserine ⁄ threonine binding proteins in the cytosol. ... 433 okadaic acid (OA) and protein kinase inhibitor stauro- sporine (ST) are typical inhibitors that promote cell death. Both inhibitors increase MAPK-involved cell death signaling le...

Ngày tải lên: 14/02/2014, 22:20